Assay Detail
ADMET
CHEMBL4771179
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Antitubercular polyhalogenated phenothiazines and phenoselenazine with reduced binding to CNS receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.01 | 6.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL479 | THIORIDAZINE | 4.0 | 1 | 6.74 |
| CHEMBL4797066 | — | — | 1 | 6.00 |
| CHEMBL4791959 | — | — | 1 | 5.67 |
| CHEMBL4778666 | — | — | 1 | 5.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL479 | THIORIDAZINE | Ki | = | 181.0 | nM | 6.74 |
| CHEMBL4797066 | — | Ki | = | 1003.0 | nM | 6.00 |
| CHEMBL4791959 | — | Ki | = | 2149.0 | nM | 5.67 |
| CHEMBL4778666 | — | Ki | = | 2340.0 | nM | 5.63 |