Assay Detail
Functional
CHEMBL4771185
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MDA-MB-231 cells measured after 72 hrs by MTT assay
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure guided design of potent indole-based ATX inhibitors bearing hydrazone moiety with tumor suppression effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 5.60 | 6.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4781471 | — | — | 1 | 6.51 |
| CHEMBL4797813 | — | — | 1 | 6.10 |
| CHEMBL4783759 | — | — | 1 | 5.94 |
| CHEMBL4782134 | — | — | 1 | 5.92 |
| CHEMBL4781407 | — | — | 1 | 5.91 |
| CHEMBL4789070 | — | — | 1 | 5.91 |
| CHEMBL4797128 | — | — | 1 | 5.90 |
| CHEMBL4800586 | — | — | 1 | 5.84 |
| CHEMBL4798227 | — | — | 1 | 5.81 |
| CHEMBL4783040 | — | — | 1 | 5.81 |
| CHEMBL4789626 | — | — | 1 | 5.68 |
| CHEMBL4779021 | — | — | 1 | 5.63 |
| CHEMBL4800643 | — | — | 1 | 5.62 |
| CHEMBL4794345 | — | — | 1 | 5.61 |
| CHEMBL4789996 | — | — | 1 | 5.57 |
| CHEMBL4778551 | — | — | 1 | 5.57 |
| CHEMBL4776596 | — | — | 1 | 5.49 |
| CHEMBL4798803 | — | — | 1 | 5.47 |
| CHEMBL4783483 | — | — | 1 | 5.46 |
| CHEMBL4780733 | — | — | 1 | 5.43 |
| CHEMBL4778972 | — | — | 1 | 5.40 |
| CHEMBL3186509 | — | — | 1 | 5.38 |
| CHEMBL4794349 | — | — | 1 | 5.35 |
| CHEMBL4786412 | — | — | 1 | 5.30 |
| CHEMBL4776130 | — | — | 1 | 5.29 |
| CHEMBL4791877 | — | — | 1 | 5.29 |
| CHEMBL4789065 | — | — | 1 | 5.26 |
| CHEMBL3828074 | ZIRITAXESTAT | 3.0 | 1 | 5.20 |
| CHEMBL4782735 | — | — | 1 | 5.14 |
| CHEMBL4784566 | — | — | 1 | 5.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4781471 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4797813 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL4783759 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL4782134 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL4781407 | — | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL4789070 | — | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL4797128 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL4800586 | — | IC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL4798227 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL4783040 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL4789626 | — | IC50 | = | 2080.0 | nM | 5.68 |
| CHEMBL4779021 | — | IC50 | = | 2330.0 | nM | 5.63 |
| CHEMBL4800643 | — | IC50 | = | 2370.0 | nM | 5.62 |
| CHEMBL4794345 | — | IC50 | = | 2430.0 | nM | 5.61 |
| CHEMBL4778551 | — | IC50 | = | 2690.0 | nM | 5.57 |
| CHEMBL4789996 | — | IC50 | = | 2720.0 | nM | 5.57 |
| CHEMBL4776596 | — | IC50 | = | 3210.0 | nM | 5.49 |
| CHEMBL4798803 | — | IC50 | = | 3410.0 | nM | 5.47 |
| CHEMBL4783483 | — | IC50 | = | 3490.0 | nM | 5.46 |
| CHEMBL4780733 | — | IC50 | = | 3670.0 | nM | 5.43 |
| CHEMBL4778972 | — | IC50 | = | 3980.0 | nM | 5.40 |
| CHEMBL3186509 | — | IC50 | = | 4170.0 | nM | 5.38 |
| CHEMBL4794349 | — | IC50 | = | 4510.0 | nM | 5.35 |
| CHEMBL4786412 | — | IC50 | = | 4970.0 | nM | 5.30 |
| CHEMBL4776130 | — | IC50 | = | 5120.0 | nM | 5.29 |
| CHEMBL4791877 | — | IC50 | = | 5170.0 | nM | 5.29 |
| CHEMBL4789065 | — | IC50 | = | 5460.0 | nM | 5.26 |
| CHEMBL3828074 | ZIRITAXESTAT | IC50 | = | 6270.0 | nM | 5.20 |
| CHEMBL4782735 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL4784566 | — | IC50 | = | 8210.0 | nM | 5.09 |
| CHEMBL4788199 | — | IC50 | - | — | - | |
| CHEMBL4780782 | — | IC50 | - | — | - | |
| CHEMBL4789880 | — | IC50 | - | — | - | |
| CHEMBL4778480 | — | IC50 | - | — | - | |
| CHEMBL4788333 | — | IC50 | - | — | - | |
| CHEMBL4786557 | — | IC50 | - | — | - | |
| CHEMBL4776428 | — | IC50 | - | — | - | |
| CHEMBL4778764 | — | IC50 | - | — | - | |
| CHEMBL4778510 | — | IC50 | - | — | - | |
| CHEMBL4800474 | — | IC50 | - | — | - |