Assay Detail
Binding
CHEMBL4771496
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human full length recombinant HDAC6 using p53 (379 to 382 residues) (RHKK(Ac)AMC) as substrate preincubated for 5 to 10 mins followed by substrate addition and measured after 2 hrs by fluorescence method
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Thirty Years of HDAC Inhibitors: 2020 Insight and Hindsight.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.55 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4536605 | — | — | 1 | 8.70 |
| CHEMBL2018302 | TUBASTATIN A | — | 1 | 8.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4536605 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2018302 | TUBASTATIN A | IC50 | = | 4.0 | nM | 8.40 |