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Assay Detail

CHEMBL4771698

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of recombinant Candida albicans SAP2 using Dabcyl-Arg-Lys-Pro-Ala-Leu-Phe-Phe-Arg-Leu-Glu (EDANS)-Arg-OH as substrate incubated for 30 mins followed by substrate addition and measured after 30 mins by spectrophotometry
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Candida albicans
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Targeting fungal virulence factor by small molecules: Structure-based discovery of novel secreted aspartic protease 2 (SAP2) inhibitors.
Li C,Liu Y,Wu S,Han G,Tu J,Dong G,Liu N,Sheng C
Eur J Med Chem (2020) 201 : 112515 -112515
PubMed 32623209 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 38 4.72 7.66

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL296588 PEPSTATIN 2.0 1 7.66
CHEMBL4796138 1 6.04
CHEMBL4291901 1 5.30
CHEMBL4792264 1 5.00
CHEMBL4795562 1 4.97
CHEMBL4782165 1 4.94
CHEMBL4799500 1 4.89
CHEMBL4784752 1 4.87
CHEMBL4796047 1 4.80
CHEMBL4790189 1 4.76
CHEMBL4799441 1 4.75
CHEMBL4798351 1 4.74
CHEMBL4779916 1 4.73
CHEMBL4787669 1 4.69
CHEMBL4790685 1 4.67
CHEMBL4799543 1 4.67
CHEMBL4778181 1 4.65
CHEMBL4788441 1 4.64
CHEMBL4790817 1 4.62
CHEMBL4800016 1 4.58
CHEMBL4798632 1 4.49
CHEMBL4776184 1 4.47
CHEMBL4799446 1 4.40
CHEMBL4785415 1 4.34
CHEMBL4781258 1 4.33
CHEMBL4783359 1 4.26
CHEMBL4794260 1 4.21
CHEMBL4777735 1 4.19
CHEMBL4785793 1 4.15
CHEMBL4791110 1 4.14

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL296588 PEPSTATIN IC50 = 22.0 nM 7.66
CHEMBL4796138 IC50 = 920.0 nM 6.04
CHEMBL4291901 IC50 = 5040.0 nM 5.30
CHEMBL4792264 IC50 = 10050.0 nM 5.00
CHEMBL4795562 IC50 = 10750.0 nM 4.97
CHEMBL4782165 IC50 = 11540.0 nM 4.94
CHEMBL4799500 IC50 = 12960.0 nM 4.89
CHEMBL4784752 IC50 = 13530.0 nM 4.87
CHEMBL4796047 IC50 = 15670.0 nM 4.80
CHEMBL4790189 IC50 = 17430.0 nM 4.76
CHEMBL4799441 IC50 = 17940.0 nM 4.75
CHEMBL4798351 IC50 = 18170.0 nM 4.74
CHEMBL4779916 IC50 = 18460.0 nM 4.73
CHEMBL4787669 IC50 = 20440.0 nM 4.69
CHEMBL4799543 IC50 = 21470.0 nM 4.67
CHEMBL4790685 IC50 = 21560.0 nM 4.67
CHEMBL4778181 IC50 = 22340.0 nM 4.65
CHEMBL4788441 IC50 = 22720.0 nM 4.64
CHEMBL4790817 IC50 = 23770.0 nM 4.62
CHEMBL4800016 IC50 = 26360.0 nM 4.58
CHEMBL4798632 IC50 = 32720.0 nM 4.49
CHEMBL4776184 IC50 = 33740.0 nM 4.47
CHEMBL4799446 IC50 = 39610.0 nM 4.40
CHEMBL4785415 IC50 = 46050.0 nM 4.34
CHEMBL4781258 IC50 = 46860.0 nM 4.33
CHEMBL4783359 IC50 = 55480.0 nM 4.26
CHEMBL4794260 IC50 = 62150.0 nM 4.21
CHEMBL4777735 IC50 = 63980.0 nM 4.19
CHEMBL4785793 IC50 = 70650.0 nM 4.15
CHEMBL4791110 IC50 = 72310.0 nM 4.14
CHEMBL4789962 IC50 = 75150.0 nM 4.12
CHEMBL4283627 IC50 = 92300.0 nM 4.04
CHEMBL4800207 IC50 - -
CHEMBL4788744 IC50 - -
CHEMBL4798981 IC50 - -
CHEMBL4798576 IC50 - -
CHEMBL1277945 IC50 - -
CHEMBL4795889 IC50 - -