Assay Detail
Functional
CHEMBL4771903
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Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 72 hrs by resazurin assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of Na/K-ATP-ase inhibiting and cytotoxic in vitro activities of oleandrigenin and its selected 17β-(butenolidyl)- and 17β-(3-furyl)- analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.27 | 7.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4285883 | OLEANDRIN | 1.0 | 1 | 7.21 |
| CHEMBL374839 | — | — | 1 | 6.70 |
| CHEMBL1080313 | GITOXIGENIN DIACETATE | — | 1 | 5.96 |
| CHEMBL4790596 | — | — | 1 | 4.85 |
| CHEMBL4795790 | — | — | 1 | 4.84 |
| CHEMBL4800377 | — | — | 1 | 4.57 |
| CHEMBL4799067 | — | — | 1 | 4.49 |
| CHEMBL4780990 | — | — | 1 | 4.47 |
| CHEMBL4783266 | — | — | 1 | 4.37 |
| CHEMBL4785189 | — | — | 1 | - |
| CHEMBL4798674 | — | — | 1 | - |
| CHEMBL4789128 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4285883 | OLEANDRIN | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL374839 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1080313 | GITOXIGENIN DIACETATE | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4790596 | — | IC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL4795790 | — | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL4800377 | — | IC50 | = | 26700.0 | nM | 4.57 |
| CHEMBL4799067 | — | IC50 | = | 32300.0 | nM | 4.49 |
| CHEMBL4780990 | — | IC50 | = | 34100.0 | nM | 4.47 |
| CHEMBL4783266 | — | IC50 | = | 43100.0 | nM | 4.37 |
| CHEMBL4785189 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4798674 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4789128 | — | IC50 | > | 50000.0 | nM | - |