Assay Detail

CHEMBL4771965

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Antileishmanial activity against Leishmania donovani BOB (MHOM/SD/62/1S-CL2D) promastigotes overexpressing NTR1 incubated for 72 hrs by resazurin dye based assay

ChEMBL ↗

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Target

Leishmania donovani (CHEMBL367) ↗

Open DB target context

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Leishmania donovani (CHEMBL367) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Leishmania donovani

CHEMBL367

Anchored from Assay target.

Protein identity Leishmania donovani

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Leishmania donovani
Confidence	1 — Organism
Curated By	Autocuration

Target

Leishmania donovani (CHEMBL367) ↗

Type	ORGANISM
Organism	Leishmania donovani

Publication

8-Alkynyl-3-nitroimidazopyridines display potent antitrypanosomal activity against both T. b. brucei and cruzi.

Fersing C,Boudot C,Castera-Ducros C,Pinault E,Hutter S,Paoli-Lombardo R,Primas N,Pedron J,Seguy L,Bourgeade-Delmas S,Sournia-Saquet A,Stigliani JL,Brossas JY,Paris L,Valentin A,Wyllie S,Fairlamb AH,Boutet-Robinet É,Corvaisier S,Since M,Malzert-Fréon A,Destere A,Mazier D,Rathelot P,Courtioux B,Azas N,Verhaeghe P,Vanelle P
Eur J Med Chem (2020) 202 : 112558 -112558
PubMed 32652409 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	2	6.35	6.40

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4780415	—	—	1	6.40
CHEMBL4787217	—	—	1	6.30

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4780415	—	EC50	=	400.0	nM	6.40
CHEMBL4787217	—	EC50	=	500.0	nM	6.30