Assay Detail
Binding
CHEMBL4772210
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Binding affinity to HSP90 (unknown origin) assessed as dissociation constant by isothermal titration calorimetry
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis, structure and anticancer activity of new geldanamycin amine analogs containing C(17)- or C(20)- flexible and rigid arms as well as closed or open ansa-bridges.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 9 | 5.93 | 6.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4788059 | — | — | 1 | 6.09 |
| CHEMBL4799459 | — | — | 1 | 6.05 |
| CHEMBL4796409 | — | — | 1 | 6.05 |
| CHEMBL4794663 | — | — | 1 | 6.03 |
| CHEMBL4789807 | — | — | 1 | 5.92 |
| CHEMBL4776995 | — | — | 1 | 5.86 |
| CHEMBL4777808 | — | — | 1 | 5.53 |
| CHEMBL4787237 | — | — | 1 | - |
| CHEMBL4798199 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4788059 | — | Kd | = | 820.0 | nM | 6.09 |
| CHEMBL4799459 | — | Kd | = | 900.0 | nM | 6.05 |
| CHEMBL4796409 | — | Kd | = | 890.0 | nM | 6.05 |
| CHEMBL4794663 | — | Kd | = | 940.0 | nM | 6.03 |
| CHEMBL4789807 | — | Kd | = | 1190.0 | nM | 5.92 |
| CHEMBL4776995 | — | Kd | = | 1370.0 | nM | 5.86 |
| CHEMBL4777808 | — | Kd | = | 2960.0 | nM | 5.53 |
| CHEMBL4787237 | — | Kd | = | 134170.0 | nM | - |
| CHEMBL4798199 | — | Kd | = | 182770.0 | nM | - |