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Assay Detail

CHEMBL4772252

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Binding
Agonist activity at human NPFFR1 expressed in CHO cells by [35S]-GTP S binding assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Neuropeptide FF receptor 1 (CHEMBL5951)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Neuropeptide FF and Its Receptors: Therapeutic Applications and Ligand Development.
Nguyen T,Marusich J,Li JX,Zhang Y
J Med Chem (2020) 63 : 12387 -12402
PubMed 32673481 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 2 6.91 7.07

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4797394 1 7.07
CHEMBL4790994 1 6.75

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4797394 EC50 = 85.0 nM 7.07
CHEMBL4790994 EC50 = 176.0 nM 6.75