Assay Detail
Functional
CHEMBL4772376
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Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
25
Total Activities
23
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MGC-803 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of tertiary amide derivatives incorporating benzothiazole moiety as anti-gastric cancer agents in vitro via inhibiting tubulin polymerization and activating the Hippo signaling pathway.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.95 | 7.70 |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1206232 | FOSBRETABULIN | 3.0 | 1 | 7.70 |
| CHEMBL4780630 | — | — | 3 | 7.46 |
| CHEMBL4778951 | — | — | 1 | 7.15 |
| CHEMBL4778270 | — | — | 1 | 7.08 |
| CHEMBL4798909 | — | — | 1 | 7.07 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 6.97 |
| CHEMBL4799015 | — | — | 1 | 6.79 |
| CHEMBL4780947 | — | — | 1 | 6.73 |
| CHEMBL4787103 | — | — | 1 | 6.43 |
| CHEMBL4786183 | — | — | 1 | 6.38 |
| CHEMBL4776920 | — | — | 1 | 6.31 |
| CHEMBL4778523 | — | — | 1 | 6.17 |
| CHEMBL4779537 | — | — | 1 | 6.07 |
| CHEMBL4783515 | — | — | 1 | 5.20 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 5.17 |
| CHEMBL4789148 | — | — | 1 | 4.60 |
| CHEMBL4793081 | — | — | 1 | 4.47 |
| CHEMBL4796623 | — | — | 1 | 4.35 |
| CHEMBL4780338 | — | — | 1 | 4.34 |
| CHEMBL4799392 | — | — | 1 | 4.32 |
| CHEMBL4798980 | — | — | 1 | 4.27 |
| CHEMBL4791000 | — | — | 1 | - |
| CHEMBL4777451 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1206232 | FOSBRETABULIN | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4780630 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4778951 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL4778270 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL4798909 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL107 | COLCHICINE | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL4799015 | — | IC50 | = | 163.0 | nM | 6.79 |
| CHEMBL4780947 | — | IC50 | = | 187.0 | nM | 6.73 |
| CHEMBL4787103 | — | IC50 | = | 372.0 | nM | 6.43 |
| CHEMBL4786183 | — | IC50 | = | 416.0 | nM | 6.38 |
| CHEMBL4776920 | — | IC50 | = | 493.0 | nM | 6.31 |
| CHEMBL4778523 | — | IC50 | = | 682.0 | nM | 6.17 |
| CHEMBL4779537 | — | IC50 | = | 852.0 | nM | 6.07 |
| CHEMBL4783515 | — | IC50 | = | 6360.0 | nM | 5.20 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 6820.0 | nM | 5.17 |
| CHEMBL4789148 | — | IC50 | = | 25200.0 | nM | 4.60 |
| CHEMBL4793081 | — | IC50 | = | 34100.0 | nM | 4.47 |
| CHEMBL4796623 | — | IC50 | = | 44300.0 | nM | 4.35 |
| CHEMBL4780338 | — | IC50 | = | 45700.0 | nM | 4.34 |
| CHEMBL4799392 | — | IC50 | = | 48100.0 | nM | 4.32 |
| CHEMBL4798980 | — | IC50 | = | 54200.0 | nM | 4.27 |
| CHEMBL4780630 | — | Inhibition | - | % | - | |
| CHEMBL4780630 | — | Inhibition | - | % | - | |
| CHEMBL4791000 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL4777451 | — | IC50 | > | 80000.0 | nM | - |