Assay Detail
Functional
CHEMBL4772378
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Antiproliferative activity against human PC-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of tertiary amide derivatives incorporating benzothiazole moiety as anti-gastric cancer agents in vitro via inhibiting tubulin polymerization and activating the Hippo signaling pathway.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.11 | 7.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1206232 | FOSBRETABULIN | 3.0 | 1 | 7.48 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 6.47 |
| CHEMBL4780630 | — | — | 1 | 5.68 |
| CHEMBL4778951 | — | — | 1 | 5.39 |
| CHEMBL4778270 | — | — | 1 | 5.12 |
| CHEMBL4787103 | — | — | 1 | 5.09 |
| CHEMBL4799015 | — | — | 1 | 5.07 |
| CHEMBL4798909 | — | — | 1 | 4.95 |
| CHEMBL4776920 | — | — | 1 | 4.91 |
| CHEMBL4780947 | — | — | 1 | 4.84 |
| CHEMBL4779537 | — | — | 1 | 4.80 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 4.74 |
| CHEMBL4786183 | — | — | 1 | 4.70 |
| CHEMBL4778523 | — | — | 1 | 4.58 |
| CHEMBL4783515 | — | — | 1 | 4.46 |
| CHEMBL4791000 | — | — | 1 | 4.29 |
| CHEMBL4796623 | — | — | 1 | 4.27 |
| CHEMBL4780338 | — | — | 1 | - |
| CHEMBL4793081 | — | — | 1 | - |
| CHEMBL4789148 | — | — | 1 | - |
| CHEMBL4777451 | — | — | 1 | - |
| CHEMBL4799392 | — | — | 1 | - |
| CHEMBL4798980 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1206232 | FOSBRETABULIN | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL107 | COLCHICINE | IC50 | = | 338.0 | nM | 6.47 |
| CHEMBL4780630 | — | IC50 | = | 2110.0 | nM | 5.68 |
| CHEMBL4778951 | — | IC50 | = | 4110.0 | nM | 5.39 |
| CHEMBL4778270 | — | IC50 | = | 7510.0 | nM | 5.12 |
| CHEMBL4787103 | — | IC50 | = | 8210.0 | nM | 5.09 |
| CHEMBL4799015 | — | IC50 | = | 8460.0 | nM | 5.07 |
| CHEMBL4798909 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL4776920 | — | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL4780947 | — | IC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL4779537 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 18400.0 | nM | 4.74 |
| CHEMBL4786183 | — | IC50 | = | 20100.0 | nM | 4.70 |
| CHEMBL4778523 | — | IC50 | = | 26500.0 | nM | 4.58 |
| CHEMBL4783515 | — | IC50 | = | 34300.0 | nM | 4.46 |
| CHEMBL4791000 | — | IC50 | = | 50820.0 | nM | 4.29 |
| CHEMBL4796623 | — | IC50 | = | 54100.0 | nM | 4.27 |
| CHEMBL4780338 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL4793081 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL4789148 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL4777451 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL4799392 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL4798980 | — | IC50 | > | 80000.0 | nM | - |