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Assay Detail

CHEMBL4772703

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of envelope glycoprotein in HIV pseudotyped Marburgvirus infected in human A549 cells assessed as reduction in virus entry measured after 48 hrs by luciferase reporter gene assay
ChEMBL ↗
59
Total Activities
59
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Marburgvirus
Cell Type A549
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

Development of coumarine derivatives as potent anti-filovirus entry inhibitors targeting viral glycoprotein.
Gao Y,Cheng H,Khan S,Xiao G,Rong L,Bai C
Eur J Med Chem (2020) 204 : 112595 -112595
PubMed 32707357 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 59 5.48 6.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4793183 — — 1 6.05
CHEMBL4777650 — — 1 6.00
CHEMBL4785768 — — 1 5.96
CHEMBL4788712 — — 1 5.96
CHEMBL4787971 — — 1 5.96
CHEMBL4796046 — — 1 5.92
CHEMBL4791664 — — 1 5.92
CHEMBL4792251 — — 1 5.92
CHEMBL4795185 — — 1 5.92
CHEMBL4782863 — — 1 5.89
CHEMBL4777266 — — 1 5.89
CHEMBL4777565 — — 1 5.89
CHEMBL4790313 — — 1 5.89
CHEMBL4784588 — — 1 5.85
CHEMBL4776723 — — 1 5.85
CHEMBL4795945 — — 1 5.77
CHEMBL4780348 — — 1 5.77
CHEMBL4776463 — — 1 5.75
CHEMBL4789857 — — 1 5.68
CHEMBL4798056 — — 1 5.66
CHEMBL4783355 — — 1 5.66
CHEMBL4780989 — — 1 5.66
CHEMBL4792927 — — 1 5.64
CHEMBL4791983 — — 1 5.62
CHEMBL4795840 — — 1 5.62
CHEMBL4791150 — — 1 5.57
CHEMBL4799545 — — 1 5.57
CHEMBL4799401 — — 1 5.55
CHEMBL4786186 — — 1 5.54
CHEMBL4778819 — — 1 5.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4793183 — IC50 = 900.0 nM 6.05
CHEMBL4777650 — IC50 = 1000.0 nM 6.00
CHEMBL4788712 — IC50 = 1100.0 nM 5.96
CHEMBL4787971 — IC50 = 1100.0 nM 5.96
CHEMBL4785768 — IC50 = 1100.0 nM 5.96
CHEMBL4796046 — IC50 = 1200.0 nM 5.92
CHEMBL4791664 — IC50 = 1200.0 nM 5.92
CHEMBL4792251 — IC50 = 1200.0 nM 5.92
CHEMBL4795185 — IC50 = 1200.0 nM 5.92
CHEMBL4782863 — IC50 = 1300.0 nM 5.89
CHEMBL4777266 — IC50 = 1300.0 nM 5.89
CHEMBL4777565 — IC50 = 1300.0 nM 5.89
CHEMBL4790313 — IC50 = 1300.0 nM 5.89
CHEMBL4776723 — IC50 = 1400.0 nM 5.85
CHEMBL4784588 — IC50 = 1400.0 nM 5.85
CHEMBL4795945 — IC50 = 1700.0 nM 5.77
CHEMBL4780348 — IC50 = 1700.0 nM 5.77
CHEMBL4776463 — IC50 = 1800.0 nM 5.75
CHEMBL4789857 — IC50 = 2100.0 nM 5.68
CHEMBL4798056 — IC50 = 2200.0 nM 5.66
CHEMBL4783355 — IC50 = 2200.0 nM 5.66
CHEMBL4780989 — IC50 = 2200.0 nM 5.66
CHEMBL4792927 — IC50 = 2300.0 nM 5.64
CHEMBL4791983 — IC50 = 2400.0 nM 5.62
CHEMBL4795840 — IC50 = 2400.0 nM 5.62
CHEMBL4791150 — IC50 = 2700.0 nM 5.57
CHEMBL4799545 — IC50 = 2700.0 nM 5.57
CHEMBL4799401 — IC50 = 2800.0 nM 5.55
CHEMBL4786186 — IC50 = 2900.0 nM 5.54
CHEMBL4778819 — IC50 = 3000.0 nM 5.52
CHEMBL4778474 — IC50 = 3000.0 nM 5.52
CHEMBL4779538 — IC50 = 3200.0 nM 5.50
CHEMBL4789921 — IC50 = 3200.0 nM 5.50
CHEMBL4778254 — IC50 = 3500.0 nM 5.46
CHEMBL4777278 — IC50 = 4200.0 nM 5.38
CHEMBL4798582 — IC50 = 5200.0 nM 5.28
CHEMBL4800331 — IC50 = 5200.0 nM 5.28
CHEMBL4795740 — IC50 = 5600.0 nM 5.25
CHEMBL4796442 — IC50 = 5800.0 nM 5.24
CHEMBL4795633 — IC50 = 5900.0 nM 5.23
CHEMBL4793904 — IC50 = 6500.0 nM 5.19
CHEMBL4778336 — IC50 = 8000.0 nM 5.10
CHEMBL4778623 — IC50 = 8200.0 nM 5.09
CHEMBL4788290 — IC50 = 8400.0 nM 5.08
CHEMBL4777041 — IC50 = 8400.0 nM 5.08
CHEMBL4796303 — IC50 = 8800.0 nM 5.06
CHEMBL4796680 — IC50 = 9100.0 nM 5.04
CHEMBL4795984 — IC50 = 12100.0 nM 4.92
CHEMBL4787057 — IC50 = 11900.0 nM 4.92
CHEMBL4783965 — IC50 = 13400.0 nM 4.87