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Assay Detail

CHEMBL4772710

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human recombinant S100P/RAGE interaction incubated for 1 hr and measured at 100 nM by ELISA based binding assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Discovery of novel small molecule inhibitors of S100P with in vitro anti-metastatic effects on pancreatic cancer cells.
Camara R,Ogbeni D,Gerstmann L,Ostovar M,Hurer E,Scott M,Mahmoud NG,Radon T,Crnogorac-Jurcevic T,Patel P,Mackenzie LS,Chau DYS,Kirton SB,Rossiter S
Eur J Med Chem (2020) 203 : 112621 -112621
PubMed 32707527 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 8.18 9.32

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4797038 1 9.32
CHEMBL4791219 1 9.29
CHEMBL4776927 1 9.26
CHEMBL4789650 1 9.22
CHEMBL4778482 1 9.10
CHEMBL4791820 1 8.89
CHEMBL4778710 1 8.38
CHEMBL4793118 1 8.16
CHEMBL4784354 1 8.11
CHEMBL4791308 1 7.86
CHEMBL3191438 1 7.72
CHEMBL4794659 1 7.64
CHEMBL4784003 1 7.37
CHEMBL4521239 1 7.11
CHEMBL4799826 1 6.90
CHEMBL1577938 1 6.58

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4797038 IC50 = 0.482 nM 9.32
CHEMBL4791219 IC50 = 0.514 nM 9.29
CHEMBL4776927 IC50 = 0.555 nM 9.26
CHEMBL4789650 IC50 = 0.6 nM 9.22
CHEMBL4778482 IC50 = 0.796 nM 9.10
CHEMBL4791820 IC50 = 1.3 nM 8.89
CHEMBL4778710 IC50 = 4.15 nM 8.38
CHEMBL4793118 IC50 = 6.89 nM 8.16
CHEMBL4784354 IC50 = 7.7 nM 8.11
CHEMBL4791308 IC50 = 13.9 nM 7.86
CHEMBL3191438 IC50 = 19.0 nM 7.72
CHEMBL4794659 IC50 = 22.7 nM 7.64
CHEMBL4784003 IC50 = 42.6 nM 7.37
CHEMBL4521239 IC50 = 77.0 nM 7.11
CHEMBL4799826 IC50 = 126.0 nM 6.90
CHEMBL1577938 IC50 = 264.0 nM 6.58