Assay Detail
Functional
CHEMBL4772844
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human QGY-7703 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | QGY-7703 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of 5-((8-methoxy-2-methylquinolin-4-yl)amino)-1H-indole-2-carbohydrazide derivatives as novel Nur77 modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 5.47 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4788605 | — | — | 1 | 6.40 |
| CHEMBL4795792 | — | — | 1 | 6.05 |
| CHEMBL4799898 | — | — | 1 | 5.97 |
| CHEMBL4798475 | — | — | 1 | 5.82 |
| CHEMBL4791147 | — | — | 1 | 5.76 |
| CHEMBL4784316 | — | — | 1 | 5.72 |
| CHEMBL4782538 | — | — | 1 | 5.71 |
| CHEMBL4798991 | — | — | 1 | 5.63 |
| CHEMBL1180 | O-DEMETHYLATED ADAPALENE | — | 1 | 5.62 |
| CHEMBL301982 | CELASTROL | — | 1 | 5.61 |
| CHEMBL4793554 | — | — | 1 | 5.61 |
| CHEMBL4792916 | — | — | 1 | 5.47 |
| CHEMBL4779087 | — | — | 1 | 5.42 |
| CHEMBL4788874 | — | — | 1 | 5.40 |
| CHEMBL4799676 | — | — | 1 | 5.34 |
| CHEMBL4795968 | — | — | 1 | 5.30 |
| CHEMBL4799755 | — | — | 1 | 5.27 |
| CHEMBL4781982 | — | — | 1 | 5.27 |
| CHEMBL4790043 | — | — | 1 | 5.03 |
| CHEMBL4779117 | — | — | 1 | 4.89 |
| CHEMBL4797746 | — | — | 1 | 4.85 |
| CHEMBL4792104 | — | — | 1 | 4.85 |
| CHEMBL4797761 | — | — | 1 | 4.81 |
| CHEMBL4784837 | — | — | 1 | - |
| CHEMBL4782181 | — | — | 1 | - |
| CHEMBL4794476 | — | — | 1 | - |
| CHEMBL4779009 | — | — | 1 | - |
| CHEMBL4784368 | — | — | 1 | - |
| CHEMBL4782279 | — | — | 1 | - |
| CHEMBL4781142 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4788605 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4795792 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL4799898 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL4798475 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL4791147 | — | IC50 | = | 1740.0 | nM | 5.76 |
| CHEMBL4784316 | — | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL4782538 | — | IC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL4798991 | — | IC50 | = | 2360.0 | nM | 5.63 |
| CHEMBL1180 | O-DEMETHYLATED ADAPALENE | IC50 | = | 2380.0 | nM | 5.62 |
| CHEMBL4793554 | — | IC50 | = | 2430.0 | nM | 5.61 |
| CHEMBL301982 | CELASTROL | IC50 | = | 2430.0 | nM | 5.61 |
| CHEMBL4792916 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4779087 | — | IC50 | = | 3780.0 | nM | 5.42 |
| CHEMBL4788874 | — | IC50 | = | 4020.0 | nM | 5.40 |
| CHEMBL4799676 | — | IC50 | = | 4610.0 | nM | 5.34 |
| CHEMBL4795968 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4799755 | — | IC50 | = | 5420.0 | nM | 5.27 |
| CHEMBL4781982 | — | IC50 | = | 5390.0 | nM | 5.27 |
| CHEMBL4790043 | — | IC50 | = | 9310.0 | nM | 5.03 |
| CHEMBL4779117 | — | IC50 | = | 12740.0 | nM | 4.89 |
| CHEMBL4797746 | — | IC50 | = | 14080.0 | nM | 4.85 |
| CHEMBL4792104 | — | IC50 | = | 14130.0 | nM | 4.85 |
| CHEMBL4797761 | — | IC50 | = | 15460.0 | nM | 4.81 |
| CHEMBL4780284 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4790928 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4779740 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4797331 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4780326 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4798766 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4776883 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4781142 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4782279 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4784368 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4779009 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4794476 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4782181 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4784837 | — | IC50 | > | 20000.0 | nM | - |