Assay Detail
ADMET
CHEMBL4772846
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human L02 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | L02 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of 5-((8-methoxy-2-methylquinolin-4-yl)amino)-1H-indole-2-carbohydrazide derivatives as novel Nur77 modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 5.30 | 6.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4790928 | — | — | 1 | 6.12 |
| CHEMBL4784316 | — | — | 1 | 5.92 |
| CHEMBL301982 | CELASTROL | — | 1 | 5.71 |
| CHEMBL4799755 | — | — | 1 | 5.61 |
| CHEMBL4798991 | — | — | 1 | 5.55 |
| CHEMBL4782538 | — | — | 1 | 5.55 |
| CHEMBL4791147 | — | — | 1 | 5.50 |
| CHEMBL4788874 | — | — | 1 | 5.45 |
| CHEMBL4799898 | — | — | 1 | 5.43 |
| CHEMBL4792916 | — | — | 1 | 5.29 |
| CHEMBL4788605 | — | — | 1 | 5.28 |
| CHEMBL4795968 | — | — | 1 | 5.24 |
| CHEMBL4798475 | — | — | 1 | 5.20 |
| CHEMBL4782181 | — | — | 1 | 5.14 |
| CHEMBL4799676 | — | — | 1 | 5.04 |
| CHEMBL4797746 | — | — | 1 | 5.03 |
| CHEMBL4780284 | — | — | 1 | 5.01 |
| CHEMBL1180 | O-DEMETHYLATED ADAPALENE | — | 1 | 5.00 |
| CHEMBL4781142 | — | — | 1 | 4.99 |
| CHEMBL4781982 | — | — | 1 | 4.87 |
| CHEMBL4779087 | — | — | 1 | 4.86 |
| CHEMBL4780326 | — | — | 1 | 4.80 |
| CHEMBL4782279 | — | — | 1 | - |
| CHEMBL4795792 | — | — | 1 | - |
| CHEMBL4792104 | — | — | 1 | - |
| CHEMBL4790043 | — | — | 1 | - |
| CHEMBL4797761 | — | — | 1 | - |
| CHEMBL4798766 | — | — | 1 | - |
| CHEMBL4776883 | — | — | 1 | - |
| CHEMBL4793554 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4790928 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL4784316 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL301982 | CELASTROL | IC50 | = | 1940.0 | nM | 5.71 |
| CHEMBL4799755 | — | IC50 | = | 2480.0 | nM | 5.61 |
| CHEMBL4798991 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4782538 | — | IC50 | = | 2790.0 | nM | 5.55 |
| CHEMBL4791147 | — | IC50 | = | 3160.0 | nM | 5.50 |
| CHEMBL4788874 | — | IC50 | = | 3540.0 | nM | 5.45 |
| CHEMBL4799898 | — | IC50 | = | 3680.0 | nM | 5.43 |
| CHEMBL4792916 | — | IC50 | = | 5170.0 | nM | 5.29 |
| CHEMBL4788605 | — | IC50 | = | 5230.0 | nM | 5.28 |
| CHEMBL4795968 | — | IC50 | = | 5720.0 | nM | 5.24 |
| CHEMBL4798475 | — | IC50 | = | 6330.0 | nM | 5.20 |
| CHEMBL4782181 | — | IC50 | = | 7310.0 | nM | 5.14 |
| CHEMBL4799676 | — | IC50 | = | 9160.0 | nM | 5.04 |
| CHEMBL4797746 | — | IC50 | = | 9310.0 | nM | 5.03 |
| CHEMBL4780284 | — | IC50 | = | 9850.0 | nM | 5.01 |
| CHEMBL1180 | O-DEMETHYLATED ADAPALENE | IC50 | = | 10080.0 | nM | 5.00 |
| CHEMBL4781142 | — | IC50 | = | 10280.0 | nM | 4.99 |
| CHEMBL4781982 | — | IC50 | = | 13540.0 | nM | 4.87 |
| CHEMBL4779087 | — | IC50 | = | 13670.0 | nM | 4.86 |
| CHEMBL4780326 | — | IC50 | = | 15930.0 | nM | 4.80 |
| CHEMBL4779740 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4779117 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4797331 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4784837 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4794476 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4779009 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4784368 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4793554 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4776883 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4798766 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4797761 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4790043 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4792104 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4795792 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4782279 | — | IC50 | > | 20000.0 | nM | - |