Assay Detail
Binding
CHEMBL4773268
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Inhibition of TrxR in human MDA-MB-231 cells measured after 72 hrs by colorimetric method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design and synthesis of benzylidenecyclohexenones as TrxR inhibitors displaying high anticancer activity and inducing ROS, apoptosis, and autophagy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.45 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4794590 | — | — | 1 | 6.96 |
| CHEMBL4798503 | — | — | 1 | 6.92 |
| CHEMBL4797848 | — | — | 1 | 6.34 |
| CHEMBL4799431 | — | — | 1 | 6.20 |
| CHEMBL465843 | PIPLARTINE | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4794590 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4798503 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4797848 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL4799431 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL465843 | PIPLARTINE | IC50 | = | 1520.0 | nM | 5.82 |