Assay Detail
Binding
CHEMBL4773301
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant SHP2 (unknown origin) using pNPP as substrate measured after 30 mins
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 11 (CHEMBL3864) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological evaluation of geniposide derivatives as potent and selective PTPlB inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.60 | 5.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4788294 | — | — | 1 | 5.91 |
| CHEMBL4786441 | — | — | 1 | 5.48 |
| CHEMBL4800140 | — | — | 1 | 5.40 |
| CHEMBL462894 | GENIPOSIDE | — | 1 | - |
| CHEMBL459016 | GENIPIN | 3.0 | 1 | - |
| CHEMBL4777827 | — | — | 1 | - |
| CHEMBL4778849 | — | — | 1 | - |
| CHEMBL294467 | SODIUM VANADATE | — | 1 | - |
| CHEMBL4781365 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4788294 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL4786441 | — | IC50 | = | 3320.0 | nM | 5.48 |
| CHEMBL4800140 | — | IC50 | = | 3970.0 | nM | 5.40 |
| CHEMBL462894 | GENIPOSIDE | IC50 | > | 500000.0 | nM | - |
| CHEMBL459016 | GENIPIN | IC50 | > | 500000.0 | nM | - |
| CHEMBL4777827 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4778849 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL294467 | SODIUM VANADATE | IC50 | - | — | - | |
| CHEMBL4781365 | — | IC50 | > | 50000.0 | nM | - |