Assay Detail
Binding
CHEMBL4773310
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human 10His-tagged eIF4E expressed in Escherichia coli BL21 (DE3) cells by catalytic enzyme-linked click chemistry assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Eukaryotic translation initiation factor 4E (CHEMBL4848) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A cell-penetrant lactam-stapled peptide for targeting eIF4E protein-protein interactions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.69 | 8.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4780117 | — | — | 1 | 8.19 |
| CHEMBL4777401 | — | — | 1 | 7.66 |
| CHEMBL4461497 | — | — | 1 | 7.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4780117 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL4777401 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4461497 | — | IC50 | = | 60.0 | nM | 7.22 |