Assay Detail
Binding
CHEMBL4773313
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Binding affinity to recombinant human 10His-tagged eIF4E expressed in Escherichia coli BL21 (DE3) cells assessed as binding constant by surface plasmon resonance analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Eukaryotic translation initiation factor 4E (CHEMBL4848) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A cell-penetrant lactam-stapled peptide for targeting eIF4E protein-protein interactions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 8.19 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4780117 | — | — | 1 | 8.66 |
| CHEMBL4777401 | — | — | 1 | 8.14 |
| CHEMBL4461497 | — | — | 1 | 7.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4780117 | — | Kd | = | 2.2 | nM | 8.66 |
| CHEMBL4777401 | — | Kd | = | 7.2 | nM | 8.14 |
| CHEMBL4461497 | — | Kd | = | 17.0 | nM | 7.77 |