Assay Detail
Binding
CHEMBL4773457
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of APC-conjugated anti-human CXCR4 clone 12G5 binding to CXCR4 in human HPBALL cells measured after 3 hrs by FACS analysis
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HPBALL |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and evaluation of pyrrolidine based CXCR4 antagonists with in vivo anti-tumor metastatic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.38 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4799439 | — | — | 1 | 7.10 |
| CHEMBL4794732 | — | — | 1 | 6.67 |
| CHEMBL4783831 | — | — | 1 | 6.66 |
| CHEMBL4795444 | — | — | 1 | 6.56 |
| CHEMBL4785166 | — | — | 1 | 6.50 |
| CHEMBL18442 | PLERIXAFOR | 4.0 | 1 | 6.25 |
| CHEMBL4777987 | — | — | 1 | 6.21 |
| CHEMBL4783241 | — | — | 1 | 5.81 |
| CHEMBL4795219 | — | — | 1 | 5.62 |
| CHEMBL4797343 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4799439 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL4794732 | — | IC50 | = | 216.0 | nM | 6.67 |
| CHEMBL4783831 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4795444 | — | IC50 | = | 278.0 | nM | 6.56 |
| CHEMBL4785166 | — | IC50 | = | 319.0 | nM | 6.50 |
| CHEMBL18442 | PLERIXAFOR | IC50 | = | 561.0 | nM | 6.25 |
| CHEMBL4777987 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL4783241 | — | IC50 | = | 1546.0 | nM | 5.81 |
| CHEMBL4795219 | — | IC50 | = | 2391.0 | nM | 5.62 |
| CHEMBL4797343 | — | IC50 | > | 10000.0 | nM | - |