Assay Detail
ADMET
CHEMBL4773483
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human FKBP12 assessed as reduction in PPIase activity using succinyl-Ala-Leu-Pro-Phe-4-nitroanilide as substrate incubated for 4 mins by absorbance method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peptidyl-prolyl cis-trans isomerase FKBP1A (CHEMBL1902) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Targeting Protein Folding: A Novel Approach for the Treatment of Pathogenic Bacteria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.10 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4790993 | — | — | 1 | 6.75 |
| CHEMBL4788177 | — | — | 1 | 6.72 |
| CHEMBL4794577 | — | — | 1 | 6.66 |
| CHEMBL4798300 | — | — | 1 | 5.92 |
| CHEMBL4779246 | — | — | 1 | 4.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4790993 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4788177 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4794577 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4798300 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4779246 | — | IC50 | = | 36100.0 | nM | 4.44 |