Assay Detail
Binding
CHEMBL4773797
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Inhibition of SARS CoV2 C-terminal His6-tagged 3CL protease expressed in Escherichia coli BL21 DE3 using Thr-Ser-Ala-Val-Leu-Gln-pNA as substrate preincubated for 30 mins followed by substrate addition and measured for 20 mins by colorimetric method
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Potent inhibitors of SARS-CoV-2 3C-like protease derived from N-substituted isatin compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.56 | 7.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL358279 | — | — | 1 | 7.35 |
| CHEMBL4784404 | — | — | 1 | 7.33 |
| CHEMBL149950 | — | — | 1 | 7.28 |
| CHEMBL3545157 | TIDEGLUSIB | 2.0 | 1 | 5.72 |
| CHEMBL210525 | — | — | 1 | 4.99 |
| CHEMBL4791652 | — | — | 1 | 4.81 |
| CHEMBL379727 | — | — | 1 | 4.75 |
| CHEMBL4795325 | — | — | 1 | 4.60 |
| CHEMBL4778529 | — | — | 1 | 4.41 |
| CHEMBL209287 | — | — | 1 | 4.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL358279 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4784404 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL149950 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL3545157 | TIDEGLUSIB | IC50 | = | 1910.0 | nM | 5.72 |
| CHEMBL210525 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL4791652 | — | IC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL379727 | — | IC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL4795325 | — | IC50 | = | 24900.0 | nM | 4.60 |
| CHEMBL4778529 | — | IC50 | = | 39200.0 | nM | 4.41 |
| CHEMBL209287 | — | IC50 | = | 41800.0 | nM | 4.38 |