Assay Detail
Functional
CHEMBL4774694
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human alpha1A receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium release incubated for 40 mins by Fluo-4AM dye based fluorescence assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The one-pot synthesis of butyl-1H-indol-3-alkylcarboxylic acid derivatives in ionic liquid as potent dual-acting agent for management of BPH.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.22 | 9.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL836 | TAMSULOSIN | 4.0 | 1 | 9.49 |
| CHEMBL4792905 | — | — | 1 | 7.68 |
| CHEMBL4788144 | — | — | 1 | 7.48 |
| CHEMBL4797051 | — | — | 1 | - |
| CHEMBL4797460 | — | — | 1 | - |
| CHEMBL4785526 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL836 | TAMSULOSIN | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL4792905 | — | IC50 | = | 20.8 | nM | 7.68 |
| CHEMBL4788144 | — | IC50 | = | 32.9 | nM | 7.48 |
| CHEMBL4797051 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4797460 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4785526 | — | IC50 | > | 1000.0 | nM | - |