Assay Detail
Binding
CHEMBL4774697
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 5-alpha reductase in rat liver microsomes assessed as inhibition of DHT formation using testosterone as substrate incubated for 10 mins by NADPH assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | Microsomes |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
The one-pot synthesis of butyl-1H-indol-3-alkylcarboxylic acid derivatives in ionic liquid as potent dual-acting agent for management of BPH.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.23 | 6.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4792905 | — | — | 1 | 6.25 |
| CHEMBL710 | FINASTERIDE | 4.0 | 1 | 6.23 |
| CHEMBL4788144 | — | — | 1 | 6.21 |
| CHEMBL4797051 | — | — | 1 | - |
| CHEMBL4797460 | — | — | 1 | - |
| CHEMBL4785526 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4792905 | — | IC50 | = | 567.9 | nM | 6.25 |
| CHEMBL710 | FINASTERIDE | IC50 | = | 590.1 | nM | 6.23 |
| CHEMBL4788144 | — | IC50 | = | 612.3 | nM | 6.21 |
| CHEMBL4797051 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4797460 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4785526 | — | IC50 | > | 5000.0 | nM | - |