Assay Detail
Binding
CHEMBL4775164
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Inhibition of FAM-conjugated ssDNA binding to His-tagged wild type RAD52 (unknown origin) expressed in Rosetta2(DE3)/pLysS cells measured after 30 mins by fluorescence polarization assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthetic Lethality through the Lens of Medicinal Chemistry.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.96 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL109037 | — | — | 1 | 5.96 |
| CHEMBL275938 | AURINTRICARBOXYLIC ACID | — | 1 | - |
| CHEMBL4165444 | — | — | 1 | - |
| CHEMBL4777728 | — | — | 1 | - |
| CHEMBL4796552 | — | — | 1 | - |
| CHEMBL4785153 | — | — | 1 | - |
| CHEMBL4795092 | — | — | 1 | - |
| CHEMBL4785174 | — | — | 1 | - |
| CHEMBL4785369 | — | — | 1 | - |
| CHEMBL51483 | GOSSYPOL | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL109037 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL275938 | AURINTRICARBOXYLIC ACID | IC50 | < | 5000.0 | nM | - |
| CHEMBL4165444 | — | IC50 | < | 5000.0 | nM | - |
| CHEMBL4777728 | — | IC50 | < | 5000.0 | nM | - |
| CHEMBL4796552 | — | IC50 | < | 5000.0 | nM | - |
| CHEMBL4785153 | — | IC50 | < | 5000.0 | nM | - |
| CHEMBL4795092 | — | IC50 | < | 5000.0 | nM | - |
| CHEMBL4785174 | — | IC50 | < | 5000.0 | nM | - |
| CHEMBL4785369 | — | IC50 | < | 5000.0 | nM | - |
| CHEMBL51483 | GOSSYPOL | IC50 | < | 5000.0 | nM | - |