Assay Detail
Binding
CHEMBL4775166
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Inhibition of 6His-tagged human RD52 assessed as reduction in RD52 binding to Cy3-dT30-Cy5 ssDNA incubated for 30 mins by FRET assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthetic Lethality through the Lens of Medicinal Chemistry.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.04 | 6.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | 3.0 | 1 | 6.56 |
| CHEMBL504212 | STRICTININ | — | 1 | 5.82 |
| CHEMBL47386 | EPIGALLOCATECHIN | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL297453 | EPIGALOCATECHIN GALLATE | IC50 | = | 277.0 | nM | 6.56 |
| CHEMBL504212 | STRICTININ | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL47386 | EPIGALLOCATECHIN | IC50 | = | 1800.0 | nM | 5.75 |