Assay Detail
Functional
CHEMBL4775358
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Inhibition of Haemonchus contortus by L4 development assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Haemonchus contortus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
1-Methyl-1H-pyrazole-5-carboxamide Derivatives Exhibit Unexpected Acute Mammalian Toxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.14 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4800455 | — | — | 1 | 9.52 |
| CHEMBL4791839 | — | — | 1 | 9.05 |
| CHEMBL4794370 | — | — | 1 | 9.00 |
| CHEMBL4788918 | — | — | 1 | 8.70 |
| CHEMBL4776646 | — | — | 1 | 8.00 |
| CHEMBL2229099 | TOLFENPYRAD | — | 1 | 7.70 |
| CHEMBL4800430 | — | — | 1 | 7.52 |
| CHEMBL2289591 | — | — | 1 | 7.10 |
| CHEMBL4777403 | — | — | 1 | 6.70 |
| CHEMBL4793219 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4800455 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4791839 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4794370 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4788918 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4776646 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2229099 | TOLFENPYRAD | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4800430 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2289591 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4777403 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4793219 | — | IC50 | < | 0.7 | nM | - |