Assay Detail
Toxicity
CHEMBL4775366
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Toxicity in rat FAO cells assessed as reduction in cellular respiration incubated over 1 hrs by extracellular flux analyzer based assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Rattus norvegicus |
| Cell Type | FAO |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
1-Methyl-1H-pyrazole-5-carboxamide Derivatives Exhibit Unexpected Acute Mammalian Toxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.00 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4800455 | — | — | 1 | 6.82 |
| CHEMBL4788918 | — | — | 1 | 6.80 |
| CHEMBL2289591 | — | — | 1 | 6.29 |
| CHEMBL2229099 | TOLFENPYRAD | — | 1 | 5.96 |
| CHEMBL4793219 | — | — | 1 | 5.90 |
| CHEMBL4777403 | — | — | 1 | 5.89 |
| CHEMBL4794370 | — | — | 1 | 5.77 |
| CHEMBL4800430 | — | — | 1 | 5.72 |
| CHEMBL4791839 | — | — | 1 | 5.43 |
| CHEMBL4776646 | — | — | 1 | 5.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4800455 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4788918 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL2289591 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL2229099 | TOLFENPYRAD | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4793219 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL4777403 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4794370 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4800430 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4791839 | — | IC50 | = | 3730.0 | nM | 5.43 |
| CHEMBL4776646 | — | IC50 | = | 4300.0 | nM | 5.37 |