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Assay Detail

CHEMBL4775434

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to human integrin alphaVbeta3 incubated for 1 hr by ELISA based solid phase integrin binding assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 6 — Multiple protein complex / RNA
Curated By Autocuration

Target

Integrin alpha-V/beta-3 (CHEMBL1907598)
Type PROTEIN COMPLEX
Organism Homo sapiens

Publication

Tuning the Biological Activity of RGD Peptides with Halotryptophans†.
Kemker I,Schröder DC,Feiner RC,Müller KM,Marion A,Sewald N
J Med Chem (2021) 64 : 586 -601
PubMed 33356253 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 9.03 9.62

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4787835 1 9.62
CHEMBL4798050 1 9.47
CHEMBL4782291 1 9.46
CHEMBL4794071 1 9.37
CHEMBL4791029 1 9.28
CHEMBL4798169 1 9.28
CHEMBL4790959 1 9.28
CHEMBL4787559 1 9.28
CHEMBL429876 CILENGITIDE 3.0 1 9.27
CHEMBL4795994 1 9.23
CHEMBL4798049 1 9.21
CHEMBL4793182 1 9.13
CHEMBL4787675 1 8.94
CHEMBL4800039 1 8.86
CHEMBL4787900 1 8.29
CHEMBL4799980 1 6.51

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4787835 IC50 = 0.24 nM 9.62
CHEMBL4798050 IC50 = 0.34 nM 9.47
CHEMBL4782291 IC50 = 0.35 nM 9.46
CHEMBL4794071 IC50 = 0.43 nM 9.37
CHEMBL4791029 IC50 = 0.53 nM 9.28
CHEMBL4798169 IC50 = 0.53 nM 9.28
CHEMBL4790959 IC50 = 0.52 nM 9.28
CHEMBL4787559 IC50 = 0.52 nM 9.28
CHEMBL429876 CILENGITIDE IC50 = 0.54 nM 9.27
CHEMBL4795994 IC50 = 0.59 nM 9.23
CHEMBL4798049 IC50 = 0.62 nM 9.21
CHEMBL4793182 IC50 = 0.74 nM 9.13
CHEMBL4787675 IC50 = 1.15 nM 8.94
CHEMBL4800039 IC50 = 1.37 nM 8.86
CHEMBL4787900 IC50 = 5.11 nM 8.29
CHEMBL4799980 IC50 = 311.0 nM 6.51