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Assay Detail

CHEMBL4775586

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human alpha-2,6-ST6GAL1 assessed as reduction in sialylated-product formation using Gal-beta1-4GlcNac and CMP-NeuSAc incubated for 15 mins by reverse-phase HPLC analysis
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Beta-galactoside alpha-2,6-sialyltransferase 1 (CHEMBL3596075)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Sialyltransferase Inhibitors Suppress Breast Cancer Metastasis.
Fu CW,Tsai HE,Chen WS,Chang TT,Chen CL,Hsiao PW,Li WS
J Med Chem (2021) 64 : 527 -542
PubMed 33371679 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 5.28 5.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3596261 1 5.82
CHEMBL4780118 1 5.44
CHEMBL4785533 1 5.38
CHEMBL4798770 1 5.36
CHEMBL4776137 1 5.34
CHEMBL4785375 1 5.31
CHEMBL4795609 1 5.30
CHEMBL4793980 1 5.30
CHEMBL4797927 1 5.29
CHEMBL4793269 1 5.27
CHEMBL4800187 1 5.25
CHEMBL4786588 1 5.24
CHEMBL4777310 1 5.24
CHEMBL4781666 1 5.17
CHEMBL4790244 1 5.14
CHEMBL4779174 1 5.12
CHEMBL4797481 1 4.80

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3596261 IC50 = 1500.0 nM 5.82
CHEMBL4780118 IC50 = 3600.0 nM 5.44
CHEMBL4785533 IC50 = 4200.0 nM 5.38
CHEMBL4798770 IC50 = 4330.0 nM 5.36
CHEMBL4776137 IC50 = 4600.0 nM 5.34
CHEMBL4785375 IC50 = 4900.0 nM 5.31
CHEMBL4795609 IC50 = 5000.0 nM 5.30
CHEMBL4793980 IC50 = 5000.0 nM 5.30
CHEMBL4797927 IC50 = 5100.0 nM 5.29
CHEMBL4793269 IC50 = 5400.0 nM 5.27
CHEMBL4800187 IC50 = 5600.0 nM 5.25
CHEMBL4786588 IC50 = 5700.0 nM 5.24
CHEMBL4777310 IC50 = 5700.0 nM 5.24
CHEMBL4781666 IC50 = 6700.0 nM 5.17
CHEMBL4790244 IC50 = 7200.0 nM 5.14
CHEMBL4779174 IC50 = 7500.0 nM 5.12
CHEMBL4797481 IC50 = 15800.0 nM 4.80