Assay Detail
Binding
CHEMBL4775698
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TNFalpha in mouse L929 cells exposed to compound incubated for 1 hr with mouse TNFalpha by luminescence based assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | L929 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.91 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4793924 | — | — | 1 | 7.00 |
| CHEMBL4787790 | — | — | 1 | 6.92 |
| CHEMBL4779359 | — | — | 1 | 6.89 |
| CHEMBL4793441 | — | — | 1 | 6.84 |
| CHEMBL4793685 | — | — | 1 | - |
| CHEMBL4783333 | — | — | 1 | - |
| CHEMBL4778232 | — | — | 1 | - |
| CHEMBL347547 | — | — | 1 | - |
| CHEMBL4777805 | — | — | 1 | - |
| CHEMBL1507048 | — | — | 1 | - |
| CHEMBL4779860 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4793924 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL4787790 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL4779359 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL4793441 | — | IC50 | = | 146.0 | nM | 6.84 |
| CHEMBL4793685 | — | IC50 | - | — | - | |
| CHEMBL4783333 | — | IC50 | - | — | - | |
| CHEMBL4778232 | — | IC50 | - | — | - | |
| CHEMBL347547 | — | IC50 | - | — | - | |
| CHEMBL4777805 | — | IC50 | - | — | - | |
| CHEMBL1507048 | — | IC50 | - | — | - | |
| CHEMBL4779860 | — | IC50 | - | — | - |