Assay Detail

CHEMBL4775957

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Binding

Inhibition of Staphylococcus aureus FabH

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Staphylococcus aureus
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Semisynthesis and Biological Evaluation of Platencin Thioether Derivatives: Dual FabF and FabH Inhibitors against MRSA.

Li Y,Weng X,Deng Y,Pan J,Zhu S,Wen Z,Yuan Y,Li S,Shen B,Duan Y,Huang Y
ACS Med Chem Lett (2021) 12 : 433 -442
PubMed 33738071 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	5.04	5.04

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1092943	PLATENCIN	—	1	5.04

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1092943	PLATENCIN	IC50	=	9200.0	nM	5.04