Assay Detail
Binding
CHEMBL4775971
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Binding affinity to His6-tagged Escherichia coli FabF C163Q mutant expressed in Escherichia coli BL21 (DE3) assessed as binding constant measured after 200 sec by isothermal titration calorimetry
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Semisynthesis and Biological Evaluation of Platencin Thioether Derivatives: Dual FabF and FabH Inhibitors against MRSA.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 7.24 | 7.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1092943 | PLATENCIN | — | 1 | 7.76 |
| CHEMBL411278 | — | — | 1 | 7.57 |
| CHEMBL4800275 | — | — | 1 | 6.99 |
| CHEMBL4793993 | — | — | 1 | 6.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1092943 | PLATENCIN | Kd | = | 17.28 | nM | 7.76 |
| CHEMBL411278 | — | Kd | = | 26.97 | nM | 7.57 |
| CHEMBL4800275 | — | Kd | = | 101.7 | nM | 6.99 |
| CHEMBL4793993 | — | Kd | = | 223.2 | nM | 6.65 |