Assay Detail
Functional
CHEMBL4806865
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of prostate specific antigen (PSA) expression in human LNCaP C4-2 cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LNCaP C4-2 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
3-amino-4-(4-(4 (dimethylcarbamoyl) phenyl)-1,4-diazepan-1-yl) thieno [2,3-b] pyridine-2-carboxamide for use in cancer therapy and formulations comprising the same
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.32 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2348353 | — | — | 1 | 7.82 |
| CHEMBL2348350 | — | — | 1 | 7.56 |
| CHEMBL4076837 | SENEXIN B | 1.0 | 1 | 6.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2348353 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL2348350 | — | IC50 | = | 27.6 | nM | 7.56 |
| CHEMBL4076837 | SENEXIN B | IC50 | = | 255.0 | nM | 6.59 |