Assay Detail
Binding
CHEMBL4808152
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Determination of IC50 values for inhibition of enzymatic assay of human HDAC6 with custom peptide substrate
151
Total Activities
148
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
HDAC6 screening dataset using tau-based substrate in an enzymatic assay yields selective inhibitors and activators
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 151 | 6.22 | 8.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL566099 | — | — | 1 | 8.81 |
| CHEMBL2364628 | RICOLINOSTAT | 2.0 | 1 | 8.43 |
| CHEMBL2018302 | TUBASTATIN A | — | 1 | 8.13 |
| CHEMBL96051 | SCRIPTAID | — | 1 | 8.07 |
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 8.06 |
| CHEMBL356066 | DACINOSTAT | 2.0 | 1 | 8.01 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.72 |
| CHEMBL353581 | PYROXAMIDE | 1.0 | 1 | 7.70 |
| CHEMBL140000 | — | — | 1 | 7.56 |
| CHEMBL2179618 | NEXTURASTAT A | — | 2 | 7.49 |
| CHEMBL1213492 | GIVINOSTAT | 4.0 | 1 | 7.46 |
| CHEMBL191482 | AR-42 | 2.0 | 1 | 7.42 |
| CHEMBL408513 | BELINOSTAT | 4.0 | 1 | 7.40 |
| CHEMBL4296717 | RESMINOSTAT | 2.0 | 1 | 7.31 |
| CHEMBL5308487 | — | — | 1 | 7.31 |
| CHEMBL483254 | PANOBINOSTAT | 4.0 | 1 | 7.27 |
| CHEMBL1164729 | FEBUXOSTAT | 4.0 | 1 | 7.26 |
| CHEMBL320497 | SUBEROHYDROXAMIC ACID | — | 1 | 7.18 |
| CHEMBL2103863 | ABEXINOSTAT | 3.0 | 1 | 7.14 |
| CHEMBL3907479 | FGFR INHIBITOR DEBIO 1347 | 2.0 | 1 | 7.08 |
| CHEMBL3622533 | FIMEPINOSTAT | 2.0 | 1 | 6.84 |
| CHEMBL3187798 | — | — | 1 | 6.73 |
| CHEMBL1851943 | PRACINOSTAT | 3.0 | 2 | 6.73 |
| CHEMBL565269 | — | — | 1 | 6.69 |
| CHEMBL88553 | — | — | 1 | 6.66 |
| CHEMBL122413 | — | — | 1 | 6.54 |
| CHEMBL242341 | FORMONONETIN | 2.0 | 2 | 6.54 |
| CHEMBL4303368 | — | — | 1 | 6.53 |
| CHEMBL256997 | ATALUREN | 4.0 | 1 | 6.52 |
| CHEMBL556667 | — | — | 1 | 6.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL566099 | — | IC50 | = | 1.551 | nM | 8.81 |
| CHEMBL2364628 | RICOLINOSTAT | IC50 | = | 3.71 | nM | 8.43 |
| CHEMBL2018302 | TUBASTATIN A | IC50 | = | 7.441 | nM | 8.13 |
| CHEMBL96051 | SCRIPTAID | IC50 | = | 8.574 | nM | 8.07 |
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 8.734 | nM | 8.06 |
| CHEMBL356066 | DACINOSTAT | IC50 | = | 9.832 | nM | 8.01 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 18.95 | nM | 7.72 |
| CHEMBL353581 | PYROXAMIDE | IC50 | = | 19.96 | nM | 7.70 |
| CHEMBL140000 | — | IC50 | = | 27.4 | nM | 7.56 |
| CHEMBL2179618 | NEXTURASTAT A | IC50 | = | 32.28 | nM | 7.49 |
| CHEMBL1213492 | GIVINOSTAT | IC50 | = | 35.02 | nM | 7.46 |
| CHEMBL191482 | AR-42 | IC50 | = | 38.27 | nM | 7.42 |
| CHEMBL408513 | BELINOSTAT | IC50 | = | 39.78 | nM | 7.40 |
| CHEMBL5308487 | — | IC50 | = | 48.97 | nM | 7.31 |
| CHEMBL4296717 | RESMINOSTAT | IC50 | = | 48.5 | nM | 7.31 |
| CHEMBL483254 | PANOBINOSTAT | IC50 | = | 53.6 | nM | 7.27 |
| CHEMBL1164729 | FEBUXOSTAT | IC50 | = | 55.42 | nM | 7.26 |
| CHEMBL2179618 | NEXTURASTAT A | IC50 | = | 60.71 | nM | 7.22 |
| CHEMBL320497 | SUBEROHYDROXAMIC ACID | IC50 | = | 65.85 | nM | 7.18 |
| CHEMBL2103863 | ABEXINOSTAT | IC50 | = | 72.19 | nM | 7.14 |
| CHEMBL3907479 | FGFR INHIBITOR DEBIO 1347 | IC50 | = | 83.75 | nM | 7.08 |
| CHEMBL3622533 | FIMEPINOSTAT | IC50 | = | 143.0 | nM | 6.84 |
| CHEMBL3187798 | — | IC50 | = | 184.5 | nM | 6.73 |
| CHEMBL1851943 | PRACINOSTAT | IC50 | = | 186.1 | nM | 6.73 |
| CHEMBL565269 | — | IC50 | = | 203.2 | nM | 6.69 |
| CHEMBL88553 | — | IC50 | = | 220.7 | nM | 6.66 |
| CHEMBL242341 | FORMONONETIN | IC50 | = | 287.9 | nM | 6.54 |
| CHEMBL122413 | — | IC50 | = | 285.7 | nM | 6.54 |
| CHEMBL4303368 | — | IC50 | = | 296.0 | nM | 6.53 |
| CHEMBL256997 | ATALUREN | IC50 | = | 300.9 | nM | 6.52 |
| CHEMBL556667 | — | IC50 | = | 333.2 | nM | 6.48 |
| CHEMBL1851943 | PRACINOSTAT | IC50 | = | 334.0 | nM | 6.48 |
| CHEMBL88612 | — | IC50 | = | 344.4 | nM | 6.46 |
| CHEMBL47529 | — | IC50 | = | 354.8 | nM | 6.45 |
| CHEMBL625 | THIABENDAZOLE | IC50 | = | 362.9 | nM | 6.44 |
| CHEMBL216543 | — | IC50 | = | 382.7 | nM | 6.42 |
| CHEMBL71191 | — | IC50 | = | 388.5 | nM | 6.41 |
| CHEMBL562551 | — | IC50 | = | 406.3 | nM | 6.39 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 403.5 | nM | 6.39 |
| CHEMBL297784 | — | IC50 | = | 426.7 | nM | 6.37 |
| CHEMBL4070705 | — | IC50 | = | 482.4 | nM | 6.32 |
| CHEMBL66654 | — | IC50 | = | 475.8 | nM | 6.32 |
| CHEMBL4303623 | — | IC50 | = | 484.7 | nM | 6.32 |
| CHEMBL15870 | INDOPROFEN | IC50 | = | 512.7 | nM | 6.29 |
| CHEMBL3589010 | — | IC50 | = | 517.9 | nM | 6.29 |
| CHEMBL90568 | DIOSMETIN | IC50 | = | 528.1 | nM | 6.28 |
| CHEMBL474991 | — | IC50 | = | 528.4 | nM | 6.28 |
| CHEMBL1773683 | EZUTROMID | IC50 | = | 527.9 | nM | 6.28 |
| CHEMBL117 | CHRYSIN | IC50 | = | 534.0 | nM | 6.27 |
| CHEMBL5308477 | — | IC50 | = | 536.0 | nM | 6.27 |