Assay Detail
Functional
CHEMBL4808772
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
42
Total Activities
41
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Novel Benzimidazole and Indazole Analogues as Tubulin Polymerization Inhibitors with Potent Anticancer Activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 6.40 | 7.75 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4852240 | — | — | 2 | 7.75 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.68 |
| CHEMBL4862445 | — | — | 1 | 7.58 |
| CHEMBL4876300 | — | — | 1 | 7.43 |
| CHEMBL4869219 | — | — | 1 | 7.37 |
| CHEMBL4868729 | — | — | 1 | 6.91 |
| CHEMBL4856193 | — | — | 1 | 6.78 |
| CHEMBL4854652 | — | — | 1 | 6.75 |
| CHEMBL4874793 | — | — | 1 | 6.61 |
| CHEMBL4865063 | — | — | 1 | 6.50 |
| CHEMBL4857795 | — | — | 1 | 6.46 |
| CHEMBL4852027 | — | — | 1 | 6.44 |
| CHEMBL4878593 | — | — | 1 | 6.22 |
| CHEMBL4861597 | — | — | 1 | 6.16 |
| CHEMBL4854410 | — | — | 1 | 5.98 |
| CHEMBL4853485 | — | — | 1 | 5.93 |
| CHEMBL4862825 | — | — | 1 | 5.62 |
| CHEMBL4863421 | — | — | 1 | 5.50 |
| CHEMBL4852235 | — | — | 1 | 5.50 |
| CHEMBL4858137 | — | — | 1 | 5.50 |
| CHEMBL4854944 | — | — | 1 | 5.21 |
| CHEMBL4873494 | — | — | 1 | 5.00 |
| CHEMBL4874994 | — | — | 1 | - |
| CHEMBL4849374 | — | — | 1 | - |
| CHEMBL4875982 | — | — | 1 | - |
| CHEMBL4872391 | — | — | 1 | - |
| CHEMBL4856548 | — | — | 1 | - |
| CHEMBL4853467 | — | — | 1 | - |
| CHEMBL4858341 | — | — | 1 | - |
| CHEMBL4848901 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4852240 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL107 | COLCHICINE | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4862445 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4876300 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL4869219 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL4868729 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL4856193 | — | IC50 | = | 168.0 | nM | 6.78 |
| CHEMBL4854652 | — | IC50 | = | 176.0 | nM | 6.75 |
| CHEMBL4874793 | — | IC50 | = | 245.0 | nM | 6.61 |
| CHEMBL4865063 | — | IC50 | = | 313.0 | nM | 6.50 |
| CHEMBL4857795 | — | IC50 | = | 349.0 | nM | 6.46 |
| CHEMBL4852027 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4878593 | — | IC50 | = | 606.0 | nM | 6.22 |
| CHEMBL4861597 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4854410 | — | IC50 | = | 1052.0 | nM | 5.98 |
| CHEMBL4853485 | — | IC50 | = | 1184.0 | nM | 5.93 |
| CHEMBL4862825 | — | IC50 | = | 2375.0 | nM | 5.62 |
| CHEMBL4863421 | — | IC50 | = | 3155.0 | nM | 5.50 |
| CHEMBL4852235 | — | IC50 | = | 3161.0 | nM | 5.50 |
| CHEMBL4858137 | — | IC50 | = | 3157.0 | nM | 5.50 |
| CHEMBL4854944 | — | IC50 | = | 6194.0 | nM | 5.21 |
| CHEMBL4873494 | — | IC50 | = | 9979.0 | nM | 5.00 |
| CHEMBL4852240 | — | Activity | - | — | - | |
| CHEMBL4874154 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4864245 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4867060 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4879370 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4874994 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4858341 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4853467 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4856548 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4872391 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4875982 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4847245 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4850895 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4879336 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4869275 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4856389 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4879129 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4848901 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4870473 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4849374 | — | IC50 | > | 10000.0 | nM | - |