Assay Detail
Functional
CHEMBL4808775
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Antiproliferative activity against mouse B16-F10 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
42
Total Activities
41
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | B16-F10 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Novel Benzimidazole and Indazole Analogues as Tubulin Polymerization Inhibitors with Potent Anticancer Activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 6.02 | 7.54 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4852240 | — | — | 2 | 7.54 |
| CHEMBL4869219 | — | — | 1 | 7.27 |
| CHEMBL4862445 | — | — | 1 | 7.19 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.08 |
| CHEMBL4868729 | — | — | 1 | 6.90 |
| CHEMBL4876300 | — | — | 1 | 6.79 |
| CHEMBL4874793 | — | — | 1 | 6.41 |
| CHEMBL4856193 | — | — | 1 | 6.35 |
| CHEMBL4878593 | — | — | 1 | 6.20 |
| CHEMBL4854652 | — | — | 1 | 6.20 |
| CHEMBL4857795 | — | — | 1 | 6.18 |
| CHEMBL4861597 | — | — | 1 | 6.13 |
| CHEMBL4865063 | — | — | 1 | 6.07 |
| CHEMBL4854410 | — | — | 1 | 5.85 |
| CHEMBL4858137 | — | — | 1 | 5.79 |
| CHEMBL4862825 | — | — | 1 | 5.77 |
| CHEMBL4852027 | — | — | 1 | 5.58 |
| CHEMBL4853485 | — | — | 1 | 5.43 |
| CHEMBL4879370 | — | — | 1 | 5.21 |
| CHEMBL4852235 | — | — | 1 | 5.15 |
| CHEMBL4848901 | — | — | 1 | 5.14 |
| CHEMBL4854944 | — | — | 1 | 5.10 |
| CHEMBL4849374 | — | — | 1 | 5.09 |
| CHEMBL4863421 | — | — | 1 | 5.07 |
| CHEMBL4873494 | — | — | 1 | 5.03 |
| CHEMBL4874994 | — | — | 1 | - |
| CHEMBL4875982 | — | — | 1 | - |
| CHEMBL4872391 | — | — | 1 | - |
| CHEMBL4856548 | — | — | 1 | - |
| CHEMBL4853467 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4852240 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4869219 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL4862445 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL107 | COLCHICINE | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL4868729 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL4876300 | — | IC50 | = | 161.4 | nM | 6.79 |
| CHEMBL4874793 | — | IC50 | = | 394.0 | nM | 6.41 |
| CHEMBL4856193 | — | IC50 | = | 443.0 | nM | 6.35 |
| CHEMBL4854652 | — | IC50 | = | 631.0 | nM | 6.20 |
| CHEMBL4878593 | — | IC50 | = | 635.0 | nM | 6.20 |
| CHEMBL4857795 | — | IC50 | = | 662.0 | nM | 6.18 |
| CHEMBL4861597 | — | IC50 | = | 746.0 | nM | 6.13 |
| CHEMBL4865063 | — | IC50 | = | 856.0 | nM | 6.07 |
| CHEMBL4854410 | — | IC50 | = | 1408.0 | nM | 5.85 |
| CHEMBL4858137 | — | IC50 | = | 1605.0 | nM | 5.79 |
| CHEMBL4862825 | — | IC50 | = | 1709.0 | nM | 5.77 |
| CHEMBL4852027 | — | IC50 | = | 2622.0 | nM | 5.58 |
| CHEMBL4853485 | — | IC50 | = | 3701.0 | nM | 5.43 |
| CHEMBL4879370 | — | IC50 | = | 6187.0 | nM | 5.21 |
| CHEMBL4852235 | — | IC50 | = | 7125.0 | nM | 5.15 |
| CHEMBL4848901 | — | IC50 | = | 7265.0 | nM | 5.14 |
| CHEMBL4854944 | — | IC50 | = | 7952.0 | nM | 5.10 |
| CHEMBL4849374 | — | IC50 | = | 8028.0 | nM | 5.09 |
| CHEMBL4863421 | — | IC50 | = | 8524.0 | nM | 5.07 |
| CHEMBL4873494 | — | IC50 | = | 9256.0 | nM | 5.03 |
| CHEMBL4847245 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4852240 | — | Activity | - | — | - | |
| CHEMBL4850895 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4864245 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4867060 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4874994 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4858341 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4853467 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4874154 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4872391 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4875982 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4879336 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4869275 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4856389 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4879129 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4870473 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4856548 | — | IC50 | > | 10000.0 | nM | - |