Assay Detail
Functional
CHEMBL4808778
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Antiproliferative activity against human A2780S cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780S |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Novel Benzimidazole and Indazole Analogues as Tubulin Polymerization Inhibitors with Potent Anticancer Activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.04 | 8.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4852240 | — | — | 1 | 8.21 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.12 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4852240 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL107 | COLCHICINE | IC50 | = | 16.7 | nM | 7.78 |