Assay Detail
Binding
CHEMBL4808935
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human CLK2 incubated for 2 hrs
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity protein kinase CLK2 (CHEMBL4225) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of 5-(3-Chlorophenylamino)benzo[<i>c</i>][2,6]naphthyridine Derivatives as Highly Selective CK2 Inhibitors with Potent Cancer Cell Stemness Inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 8.29 | 9.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1230165 | SILMITASERTIB | 2.0 | 1 | 9.26 |
| CHEMBL4848224 | — | — | 1 | 8.97 |
| CHEMBL4872225 | — | — | 1 | 8.81 |
| CHEMBL4848072 | — | — | 1 | 8.77 |
| CHEMBL4875513 | — | — | 1 | 8.62 |
| CHEMBL4875815 | — | — | 1 | 8.01 |
| CHEMBL4878998 | — | — | 1 | 7.71 |
| CHEMBL4862003 | — | — | 1 | 7.66 |
| CHEMBL4857079 | — | — | 1 | 7.61 |
| CHEMBL4860630 | — | — | 1 | 7.49 |
| CHEMBL4855171 | — | — | 1 | - |
| CHEMBL4854640 | — | — | 1 | - |
| CHEMBL4846022 | — | — | 1 | - |
| CHEMBL4852239 | — | — | 1 | - |
| CHEMBL4848229 | — | — | 1 | - |
| CHEMBL4865194 | — | — | 1 | - |
| CHEMBL4845902 | — | — | 1 | - |
| CHEMBL4873444 | — | — | 1 | - |
| CHEMBL4866502 | — | — | 1 | - |
| CHEMBL4867054 | — | — | 1 | - |
| CHEMBL4870899 | — | — | 1 | - |
| CHEMBL4850291 | — | — | 1 | - |
| CHEMBL4849246 | — | — | 1 | - |
| CHEMBL4857107 | — | — | 1 | - |
| CHEMBL4870230 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1230165 | SILMITASERTIB | IC50 | = | 0.55 | nM | 9.26 |
| CHEMBL4848224 | — | IC50 | = | 1.06 | nM | 8.97 |
| CHEMBL4872225 | — | IC50 | = | 1.54 | nM | 8.81 |
| CHEMBL4848072 | — | IC50 | = | 1.69 | nM | 8.77 |
| CHEMBL4875513 | — | IC50 | = | 2.38 | nM | 8.62 |
| CHEMBL4875815 | — | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL4878998 | — | IC50 | = | 19.64 | nM | 7.71 |
| CHEMBL4862003 | — | IC50 | = | 21.9 | nM | 7.66 |
| CHEMBL4857079 | — | IC50 | = | 24.69 | nM | 7.61 |
| CHEMBL4860630 | — | IC50 | = | 32.69 | nM | 7.49 |
| CHEMBL4855171 | — | IC50 | - | — | - | |
| CHEMBL4854640 | — | IC50 | - | — | - | |
| CHEMBL4846022 | — | IC50 | - | — | - | |
| CHEMBL4852239 | — | IC50 | - | — | - | |
| CHEMBL4848229 | — | IC50 | - | — | - | |
| CHEMBL4865194 | — | IC50 | - | — | - | |
| CHEMBL4845902 | — | IC50 | - | — | - | |
| CHEMBL4873444 | — | IC50 | - | — | - | |
| CHEMBL4866502 | — | IC50 | - | — | - | |
| CHEMBL4867054 | — | IC50 | - | — | - | |
| CHEMBL4870899 | — | IC50 | - | — | - | |
| CHEMBL4850291 | — | IC50 | - | — | - | |
| CHEMBL4849246 | — | IC50 | - | — | - | |
| CHEMBL4857107 | — | IC50 | - | — | - | |
| CHEMBL4870230 | — | IC50 | - | — | - |