Assay Detail
Functional
CHEMBL4808943
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human PC3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 5-(3-Chlorophenylamino)benzo[<i>c</i>][2,6]naphthyridine Derivatives as Highly Selective CK2 Inhibitors with Potent Cancer Cell Stemness Inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 5.06 | 5.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4862003 | — | — | 1 | 5.48 |
| CHEMBL4850291 | — | — | 1 | 5.38 |
| CHEMBL4854640 | — | — | 1 | 5.38 |
| CHEMBL4860630 | — | — | 1 | 5.34 |
| CHEMBL4867054 | — | — | 1 | 5.31 |
| CHEMBL4878998 | — | — | 1 | 5.26 |
| CHEMBL4845902 | — | — | 1 | 5.22 |
| CHEMBL4846022 | — | — | 1 | 5.21 |
| CHEMBL4848224 | — | — | 1 | 5.19 |
| CHEMBL4848229 | — | — | 1 | 5.12 |
| CHEMBL4857079 | — | — | 1 | 5.06 |
| CHEMBL4873444 | — | — | 1 | 5.05 |
| CHEMBL4875513 | — | — | 1 | 5.04 |
| CHEMBL4875815 | — | — | 1 | 5.00 |
| CHEMBL4865194 | — | — | 1 | 5.00 |
| CHEMBL4848072 | — | — | 1 | 5.00 |
| CHEMBL4849246 | — | — | 1 | 4.96 |
| CHEMBL4852239 | — | — | 1 | 4.96 |
| CHEMBL1230165 | SILMITASERTIB | 2.0 | 1 | 4.89 |
| CHEMBL4857107 | — | — | 1 | 4.87 |
| CHEMBL4866502 | — | — | 1 | 4.85 |
| CHEMBL4855171 | — | — | 1 | 4.82 |
| CHEMBL4870899 | — | — | 1 | 4.79 |
| CHEMBL4870230 | — | — | 1 | 4.72 |
| CHEMBL4872225 | — | — | 1 | 4.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4862003 | — | IC50 | = | 3280.0 | nM | 5.48 |
| CHEMBL4850291 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4854640 | — | IC50 | = | 4160.0 | nM | 5.38 |
| CHEMBL4860630 | — | IC50 | = | 4530.0 | nM | 5.34 |
| CHEMBL4867054 | — | IC50 | = | 4890.0 | nM | 5.31 |
| CHEMBL4878998 | — | IC50 | = | 5480.0 | nM | 5.26 |
| CHEMBL4845902 | — | IC50 | = | 6080.0 | nM | 5.22 |
| CHEMBL4846022 | — | IC50 | = | 6120.0 | nM | 5.21 |
| CHEMBL4848224 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL4848229 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL4857079 | — | IC50 | = | 8760.0 | nM | 5.06 |
| CHEMBL4873444 | — | IC50 | = | 8940.0 | nM | 5.05 |
| CHEMBL4875513 | — | IC50 | = | 9150.0 | nM | 5.04 |
| CHEMBL4875815 | — | IC50 | = | 9940.0 | nM | 5.00 |
| CHEMBL4865194 | — | IC50 | = | 10070.0 | nM | 5.00 |
| CHEMBL4848072 | — | IC50 | = | 10010.0 | nM | 5.00 |
| CHEMBL4849246 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL4852239 | — | IC50 | = | 11080.0 | nM | 4.96 |
| CHEMBL1230165 | SILMITASERTIB | IC50 | = | 12750.0 | nM | 4.89 |
| CHEMBL4857107 | — | IC50 | = | 13530.0 | nM | 4.87 |
| CHEMBL4866502 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL4855171 | — | IC50 | = | 15090.0 | nM | 4.82 |
| CHEMBL4870899 | — | IC50 | = | 16180.0 | nM | 4.79 |
| CHEMBL4870230 | — | IC50 | = | 19180.0 | nM | 4.72 |
| CHEMBL4872225 | — | IC50 | = | 22090.0 | nM | 4.66 |