Assay Detail
Binding
CHEMBL4809012
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Inhibition of CK2 (unknown origin)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Discovery of 5-(3-Chlorophenylamino)benzo[<i>c</i>][2,6]naphthyridine Derivatives as Highly Selective CK2 Inhibitors with Potent Cancer Cell Stemness Inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.84 | 9.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1230165 | SILMITASERTIB | 2.0 | 1 | 9.42 |
| CHEMBL4846181 | — | — | 1 | 9.38 |
| CHEMBL376505 | — | — | 1 | 7.40 |
| CHEMBL177820 | TETRABROMOBENZOTRIAZOLE | — | 1 | 6.40 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 5.93 |
| CHEMBL289277 | EMODIN | — | 1 | 5.72 |
| CHEMBL4874778 | — | — | 1 | 5.35 |
| CHEMBL30707 | COUMESTROL | — | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1230165 | SILMITASERTIB | Ki | = | 0.38 | nM | 9.42 |
| CHEMBL4846181 | — | Ki | = | 0.42 | nM | 9.38 |
| CHEMBL376505 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL177820 | TETRABROMOBENZOTRIAZOLE | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL50 | QUERCETIN | Ki | = | 1180.0 | nM | 5.93 |
| CHEMBL289277 | EMODIN | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL4874778 | — | Ki | = | 4500.0 | nM | 5.35 |
| CHEMBL30707 | COUMESTROL | Ki | = | 7670.0 | nM | 5.12 |