Assay Detail
Functional
CHEMBL4809635
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of novel imidazo[1,2-a]pyridine-oxadiazole hybrids as anti-proliferative agents: Study of microtubule polymerization inhibition and DNA binding.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 4.92 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 7.05 |
| CHEMBL4858563 | — | — | 1 | 5.55 |
| CHEMBL4848045 | — | — | 1 | 5.00 |
| CHEMBL4862551 | — | — | 1 | 4.97 |
| CHEMBL4873186 | — | — | 1 | 4.96 |
| CHEMBL4846202 | — | — | 1 | 4.92 |
| CHEMBL4874240 | — | — | 1 | 4.91 |
| CHEMBL4877553 | — | — | 1 | 4.89 |
| CHEMBL4849379 | — | — | 1 | 4.84 |
| CHEMBL4853311 | — | — | 1 | 4.63 |
| CHEMBL4850383 | — | — | 1 | 4.63 |
| CHEMBL4865800 | — | — | 1 | 4.63 |
| CHEMBL4857534 | — | — | 1 | 4.49 |
| CHEMBL4875946 | — | — | 1 | 4.48 |
| CHEMBL4873691 | — | — | 1 | 4.46 |
| CHEMBL4858778 | — | — | 1 | 4.36 |
| CHEMBL4867047 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4858563 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4848045 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL4862551 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL4873186 | — | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL4846202 | — | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL4874240 | — | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL4877553 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL4849379 | — | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL4853311 | — | IC50 | = | 23400.0 | nM | 4.63 |
| CHEMBL4850383 | — | IC50 | = | 23400.0 | nM | 4.63 |
| CHEMBL4865800 | — | IC50 | = | 23400.0 | nM | 4.63 |
| CHEMBL4857534 | — | IC50 | = | 32400.0 | nM | 4.49 |
| CHEMBL4875946 | — | IC50 | = | 33400.0 | nM | 4.48 |
| CHEMBL4873691 | — | IC50 | = | 34700.0 | nM | 4.46 |
| CHEMBL4858778 | — | IC50 | = | 43500.0 | nM | 4.36 |
| CHEMBL4867047 | — | IC50 | > | 50000.0 | nM | - |