Assay Detail
Binding
CHEMBL4810138
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Inhibition of human FGFR2 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Pemigatinib: A Potent and Selective Fibroblast Growth Factor Receptor (FGFR) Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.77 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4870179 | — | — | 1 | 9.82 |
| CHEMBL4862823 | — | — | 1 | 9.52 |
| CHEMBL4863146 | — | — | 1 | 9.00 |
| CHEMBL4847441 | — | — | 1 | 8.85 |
| CHEMBL4863224 | — | — | 1 | 8.85 |
| CHEMBL4856613 | — | — | 1 | 8.36 |
| CHEMBL4868291 | — | — | 1 | 7.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4870179 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL4862823 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4863146 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4847441 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4863224 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4856613 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL4868291 | — | IC50 | = | 97.0 | nM | 7.01 |