Assay Detail
Binding
CHEMBL4810139
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human FGFR3 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Pemigatinib: A Potent and Selective Fibroblast Growth Factor Receptor (FGFR) Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.65 | 9.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4870179 | — | — | 1 | 9.57 |
| CHEMBL4862823 | — | — | 1 | 9.31 |
| CHEMBL4863146 | — | — | 1 | 8.92 |
| CHEMBL4863224 | — | — | 1 | 8.85 |
| CHEMBL4847441 | — | — | 1 | 8.66 |
| CHEMBL4856613 | — | — | 1 | 8.24 |
| CHEMBL4868291 | — | — | 1 | 6.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4870179 | — | IC50 | = | 0.27 | nM | 9.57 |
| CHEMBL4862823 | — | IC50 | = | 0.49 | nM | 9.31 |
| CHEMBL4863146 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4863224 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4847441 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL4856613 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL4868291 | — | IC50 | = | 108.0 | nM | 6.97 |