Assay Detail
Binding
CHEMBL4810143
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Inhibition of phosphorylated FGFR2alpha in human KATO III stomach cancer cell line spiked in human whole blood incubated for 4 hrs by ELISA
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | KATO III stomach cancer cell line |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of Pemigatinib: A Potent and Selective Fibroblast Growth Factor Receptor (FGFR) Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 7.70 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4870179 | — | — | 1 | 8.22 |
| CHEMBL4873688 | — | — | 1 | 8.22 |
| CHEMBL4878157 | — | — | 1 | 8.17 |
| CHEMBL4848173 | — | — | 1 | 8.09 |
| CHEMBL4873796 | — | — | 1 | 8.07 |
| CHEMBL4297522 | PEMIGATINIB | 4.0 | 1 | 7.96 |
| CHEMBL4866175 | — | — | 1 | 7.96 |
| CHEMBL4857494 | — | — | 1 | 7.82 |
| CHEMBL4873911 | — | — | 1 | 7.82 |
| CHEMBL4848945 | — | — | 1 | 7.80 |
| CHEMBL4862823 | — | — | 1 | 7.75 |
| CHEMBL4868368 | — | — | 1 | 7.75 |
| CHEMBL4864630 | — | — | 1 | 7.75 |
| CHEMBL4853979 | — | — | 1 | 7.70 |
| CHEMBL4874112 | — | — | 1 | 7.66 |
| CHEMBL4876826 | — | — | 1 | 7.62 |
| CHEMBL4851637 | — | — | 1 | 7.60 |
| CHEMBL4864342 | — | — | 1 | 7.55 |
| CHEMBL4849808 | — | — | 1 | 7.54 |
| CHEMBL4847687 | — | — | 1 | 7.54 |
| CHEMBL4863835 | — | — | 1 | 7.50 |
| CHEMBL4846809 | — | — | 1 | 7.48 |
| CHEMBL4856966 | — | — | 1 | 7.46 |
| CHEMBL4855179 | — | — | 1 | 7.41 |
| CHEMBL4863146 | — | — | 1 | 7.19 |
| CHEMBL4863224 | — | — | 1 | 7.17 |
| CHEMBL4847441 | — | — | 1 | 7.09 |
| CHEMBL4856613 | — | — | 1 | - |
| CHEMBL4868291 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4870179 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4873688 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4878157 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL4848173 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL4873796 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL4297522 | PEMIGATINIB | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4866175 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4857494 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4873911 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4848945 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4862823 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4868368 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4864630 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4853979 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4874112 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4876826 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4851637 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4864342 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4849808 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4847687 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4863835 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4846809 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4856966 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4855179 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL4863146 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL4863224 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL4847441 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL4856613 | — | IC50 | - | — | - | |
| CHEMBL4868291 | — | IC50 | - | — | - |