Assay Detail
Binding
CHEMBL4810396
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of COX2 in human whole blood assessed as reduction in LPS stimulated PGE2 production incubated for 1 hr by ELISA
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Gut-Restricted Selective Cyclooxygenase-2 (COX-2) Inhibitors for Chemoprevention of Colorectal Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.15 | 6.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4870569 | — | — | 1 | 6.84 |
| CHEMBL4865464 | — | — | 1 | 6.46 |
| CHEMBL4859571 | — | — | 1 | 6.46 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 6.36 |
| CHEMBL416146 | ETORICOXIB | 4.0 | 1 | 6.21 |
| CHEMBL4868446 | — | — | 1 | 6.06 |
| CHEMBL4862802 | — | — | 1 | 5.63 |
| CHEMBL4857474 | — | — | 1 | 5.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4870569 | — | IC50 | = | 146.0 | nM | 6.84 |
| CHEMBL4865464 | — | IC50 | = | 346.0 | nM | 6.46 |
| CHEMBL4859571 | — | IC50 | = | 345.0 | nM | 6.46 |
| CHEMBL118 | CELECOXIB | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL416146 | ETORICOXIB | IC50 | = | 611.0 | nM | 6.21 |
| CHEMBL4868446 | — | IC50 | = | 877.0 | nM | 6.06 |
| CHEMBL4862802 | — | IC50 | = | 2341.0 | nM | 5.63 |
| CHEMBL4857474 | — | IC50 | = | 7232.0 | nM | 5.14 |