Assay Detail
Binding
CHEMBL4810465
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to Burkholderia pseudomallei IspF at pH 7.4 measured by isothermal titration calorimetry method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Burkholderia pseudomallei |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (CHEMBL3091270) ↗| Type | SINGLE PROTEIN |
| Organism | Burkholderia pseudomallei (strain K96243) |
Publication
Structural and biophysical characterization of the Burkholderia pseudomallei IspF inhibitor L-tryptophan hydroxamate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 4.32 | 4.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL490034 | — | — | 1 | 4.44 |
| CHEMBL4874588 | — | — | 1 | 4.19 |
| CHEMBL54976 | TRYPTOPHAN | 4.0 | 1 | - |
| CHEMBL292303 | D-TRYPTOPHAN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL490034 | — | Kd | = | 36000.0 | nM | 4.44 |
| CHEMBL4874588 | — | Kd | = | 64000.0 | nM | 4.19 |
| CHEMBL54976 | TRYPTOPHAN | Kd | > | 1000000.0 | nM | - |
| CHEMBL292303 | D-TRYPTOPHAN | Kd | > | 1000000.0 | nM | - |