Assay Detail
ADMET
CHEMBL4810484
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Cytotoxicity against human HEK293T cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HEK-293T |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Exploration of Benzo[b]carbazole-6,11-diones as anticancer agents: Synthesis and studies of hTopoIIα inhibition and apoptotic effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 5.12 | 5.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1631464 | — | — | 1 | 5.46 |
| CHEMBL4867612 | — | — | 1 | 5.40 |
| CHEMBL4869734 | — | — | 1 | 5.38 |
| CHEMBL3331077 | — | — | 1 | 5.35 |
| CHEMBL432368 | — | — | 1 | 5.31 |
| CHEMBL84014 | — | — | 1 | 5.28 |
| CHEMBL4853143 | — | — | 1 | 5.28 |
| CHEMBL3186937 | — | — | 1 | 5.28 |
| CHEMBL1631460 | — | — | 1 | 5.26 |
| CHEMBL3331083 | — | — | 1 | 5.25 |
| CHEMBL3185552 | — | — | 1 | 5.25 |
| CHEMBL84010 | — | — | 1 | 5.25 |
| CHEMBL362886 | BENZOCARBAZOLEDIONE | — | 1 | 5.24 |
| CHEMBL3331078 | — | — | 1 | 5.20 |
| CHEMBL4876867 | — | — | 1 | 5.20 |
| CHEMBL4869053 | — | — | 1 | 5.16 |
| CHEMBL4848884 | — | — | 1 | 5.14 |
| CHEMBL4864646 | — | — | 1 | 5.14 |
| CHEMBL4857432 | — | — | 1 | 5.12 |
| CHEMBL4871363 | — | — | 1 | 5.12 |
| CHEMBL4860625 | — | — | 1 | 5.11 |
| CHEMBL3186413 | — | — | 1 | 5.11 |
| CHEMBL4862771 | — | — | 1 | 5.10 |
| CHEMBL4649554 | — | — | 1 | 5.09 |
| CHEMBL4851409 | — | — | 1 | 5.08 |
| CHEMBL4853658 | — | — | 1 | 5.08 |
| CHEMBL4872997 | — | — | 1 | 5.05 |
| CHEMBL4871738 | — | — | 1 | 5.05 |
| CHEMBL4858722 | — | — | 1 | 5.03 |
| CHEMBL3331085 | — | — | 1 | 5.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1631464 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4867612 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4869734 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL3331077 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL432368 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL84014 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL4853143 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL3186937 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL1631460 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL3185552 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL84010 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL3331083 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL362886 | BENZOCARBAZOLEDIONE | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL3331078 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL4876867 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL4869053 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4848884 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL4864646 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL4871363 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL4857432 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL4860625 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL3186413 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL4862771 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL4649554 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL4851409 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL4853658 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL4872997 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL4871738 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL4858722 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL3331085 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL3329975 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL3331089 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL4849310 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL3331086 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL4864420 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL4870720 | — | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL4873302 | — | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL4854670 | — | IC50 | = | 30000.0 | nM | 4.52 |