Assay Detail
Functional
CHEMBL4810485
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Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Exploration of Benzo[b]carbazole-6,11-diones as anticancer agents: Synthesis and studies of hTopoIIα inhibition and apoptotic effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 44 | 5.22 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1631464 | — | — | 1 | 5.70 |
| CHEMBL3331077 | — | — | 1 | 5.68 |
| CHEMBL3331083 | — | — | 1 | 5.50 |
| CHEMBL4867612 | — | — | 1 | 5.50 |
| CHEMBL4869734 | — | — | 1 | 5.43 |
| CHEMBL432368 | — | — | 1 | 5.41 |
| CHEMBL3186937 | — | — | 1 | 5.39 |
| CHEMBL4853143 | — | — | 1 | 5.38 |
| CHEMBL4876867 | — | — | 1 | 5.36 |
| CHEMBL1631460 | — | — | 1 | 5.32 |
| CHEMBL4857432 | — | — | 1 | 5.32 |
| CHEMBL84014 | — | — | 1 | 5.31 |
| CHEMBL4862771 | — | — | 1 | 5.31 |
| CHEMBL84010 | — | — | 1 | 5.28 |
| CHEMBL3185552 | — | — | 1 | 5.28 |
| CHEMBL362886 | BENZOCARBAZOLEDIONE | — | 1 | 5.28 |
| CHEMBL4871738 | — | — | 1 | 5.27 |
| CHEMBL4848884 | — | — | 1 | 5.26 |
| CHEMBL3186413 | — | — | 1 | 5.23 |
| CHEMBL3331078 | — | — | 1 | 5.21 |
| CHEMBL4860625 | — | — | 1 | 5.21 |
| CHEMBL4871363 | — | — | 1 | 5.20 |
| CHEMBL4869053 | — | — | 1 | 5.20 |
| CHEMBL4864646 | — | — | 1 | 5.19 |
| CHEMBL4649554 | — | — | 1 | 5.19 |
| CHEMBL4853658 | — | — | 1 | 5.19 |
| CHEMBL4851409 | — | — | 1 | 5.16 |
| CHEMBL4872997 | — | — | 1 | 5.16 |
| CHEMBL4858722 | — | — | 1 | 5.16 |
| CHEMBL3331089 | — | — | 1 | 5.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1631464 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3331077 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4867612 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL3331083 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL4869734 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL432368 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL3186937 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL4853143 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4876867 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL1631460 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL4857432 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL4862771 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL84014 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL362886 | BENZOCARBAZOLEDIONE | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL3185552 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL84010 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL4871738 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL4848884 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL3186413 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL3331078 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL4860625 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL4869053 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL4871363 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL4864646 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL4649554 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL4853658 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL4851409 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL4872997 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4858722 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL3331089 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL3331085 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL4864420 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL3331086 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL4870720 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL4849310 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL3329975 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL4873302 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4854670 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL4853245 | — | IC50 | - | — | - | |
| CHEMBL4865073 | — | IC50 | - | — | - | |
| CHEMBL4853800 | — | IC50 | - | — | - | |
| CHEMBL4855462 | — | IC50 | - | — | - | |
| CHEMBL4871308 | — | IC50 | - | — | - |