Assay Detail
Functional
CHEMBL4810486
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Exploration of Benzo[b]carbazole-6,11-diones as anticancer agents: Synthesis and studies of hTopoIIα inhibition and apoptotic effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 44 | 5.24 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1631464 | — | — | 1 | 5.82 |
| CHEMBL3331077 | — | — | 1 | 5.70 |
| CHEMBL4867612 | — | — | 1 | 5.52 |
| CHEMBL3331083 | — | — | 1 | 5.51 |
| CHEMBL4869734 | — | — | 1 | 5.42 |
| CHEMBL84014 | — | — | 1 | 5.39 |
| CHEMBL432368 | — | — | 1 | 5.39 |
| CHEMBL4869053 | — | — | 1 | 5.38 |
| CHEMBL3186937 | — | — | 1 | 5.38 |
| CHEMBL4853143 | — | — | 1 | 5.38 |
| CHEMBL4848884 | — | — | 1 | 5.36 |
| CHEMBL84010 | — | — | 1 | 5.36 |
| CHEMBL1631460 | — | — | 1 | 5.35 |
| CHEMBL4876867 | — | — | 1 | 5.35 |
| CHEMBL362886 | BENZOCARBAZOLEDIONE | — | 1 | 5.35 |
| CHEMBL4857432 | — | — | 1 | 5.33 |
| CHEMBL4862771 | — | — | 1 | 5.28 |
| CHEMBL3186413 | — | — | 1 | 5.28 |
| CHEMBL4853658 | — | — | 1 | 5.27 |
| CHEMBL4860625 | — | — | 1 | 5.22 |
| CHEMBL4864646 | — | — | 1 | 5.21 |
| CHEMBL4871738 | — | — | 1 | 5.20 |
| CHEMBL4649554 | — | — | 1 | 5.20 |
| CHEMBL4871363 | — | — | 1 | 5.19 |
| CHEMBL3331078 | — | — | 1 | 5.19 |
| CHEMBL3185552 | — | — | 1 | 5.19 |
| CHEMBL4851409 | — | — | 1 | 5.16 |
| CHEMBL3331085 | — | — | 1 | 5.16 |
| CHEMBL4872997 | — | — | 1 | 5.14 |
| CHEMBL4858722 | — | — | 1 | 5.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1631464 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3331077 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4867612 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3331083 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4869734 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL84014 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL432368 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL4869053 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL3186937 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4853143 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4848884 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL84010 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL1631460 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL362886 | BENZOCARBAZOLEDIONE | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL4876867 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL4857432 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL4862771 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL3186413 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL4853658 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL4860625 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL4864646 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL4649554 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL4871738 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL4871363 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL3331078 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL3185552 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL4851409 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL3331085 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4872997 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL4858722 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL3331086 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL4864420 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL3331089 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL3329975 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL4849310 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL4870720 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL4873302 | — | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL4854670 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL4853800 | — | IC50 | - | — | - | |
| CHEMBL4865073 | — | IC50 | - | — | - | |
| CHEMBL4853245 | — | IC50 | - | — | - | |
| CHEMBL4855462 | — | IC50 | - | — | - | |
| CHEMBL4871308 | — | IC50 | - | — | - |