Assay Detail
ADMET
CHEMBL4810488
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Cytotoxicity against human MCF-10A cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | MCF-10A |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Exploration of Benzo[b]carbazole-6,11-diones as anticancer agents: Synthesis and studies of hTopoIIα inhibition and apoptotic effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.06 | 4.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1631464 | — | — | 1 | 4.07 |
| CHEMBL3331077 | — | — | 1 | 4.05 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | - |
| CHEMBL3331083 | — | — | 1 | - |
| CHEMBL4867612 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1631464 | — | IC50 | = | 86000.0 | nM | 4.07 |
| CHEMBL3331077 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL44657 | ETOPOSIDE | IC50 | > | 120000.0 | nM | - |
| CHEMBL3331083 | — | IC50 | = | 101000.0 | nM | - |
| CHEMBL4867612 | — | IC50 | = | 105000.0 | nM | - |